Syntactic structure analysis in uveal melanomas

Kate Coleman, Paul J. Van Diest, Jan P A Baak, Joan Mullaney

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Syntactic structure analysis was carried out successfully on 92 paraffin embedded uveal melanomas, taken from patients with a minimum follow up of 5 years. This simple, fast, and reproducible method of describing the tumour architecture has been significantly correlated with malignancy in tumours from several sites. Paraffin sections 5 ,um thick, were cut and stained with haematoxylin and eosin. Tumours were classified according to a modification of the Callender classification. A minimum spanning tree (MST), using the centre points of tumour nuclei, was constructed in five randomly chosen fields with an interactive digitising video overlay system. Ten syntactic structure features were derived from each MST; subsequently, the mean and standard deviation of the five fields analysed were calculated for further statistical analysis. Reproducibility was acceptable with a mean correlation coefficient of 070. In univariate survival analysis, the percentage of points with three neighbours yielded prognostic significance (p2 test) with classic tumour prognosticators and there was a significant correlation between Callender cell type and the following MST parameters: mean number of points (p

Original languageEnglish (US)
Pages (from-to)871-874
Number of pages4
JournalBritish Journal of Ophthalmology
Volume78
Issue number11
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine
  • Ophthalmology

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