@inproceedings{dac3b39effa1431296f5fb9073e03a14,
title = "Synrtgistic effects of nanotopography and surface matrix patterning on contact guided migration of human breast cancer cells",
abstract = "Cells are highly sensitive to topographic and mechanical features of the surrounding extracellular matrix (ECM) environment. Indeed, cells respond to these physical cues to coordinate adhesion-mediated signaling and the dynamic cytoskeletal remodeling underlying locomotion. Inspired by this biophysical relationship between cells and the ECM, particularly within the tumor microenvironment, we engineered an innovative biomimetic platform using substrate nanotopography and surface modification techniques in order to guide and promote the migration of oncogenic PIK3CA knockin mutants compared to their wild type non-transformed counterpart, MCF-10A human breast epithelial cells. Results demonstrate that human mammary epithelial cells collectively interact with the engineered microstructural environment, which regulates cell migration with increased velocity and persistence time.",
keywords = "Capillary force lithography, Cell patterning, Contact-guided cell migration, MCF-10A, Nanotopography, Oncogenic PIK3CA knockin mutations, Plasma lithography",
author = "Nam, {K. H.} and P. Kim and Provenzano, {P. P.} and S. Kwon and Kim, {D. H.}",
note = "Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",
year = "2015",
language = "English (US)",
series = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "221--223",
booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}