Synphilin-1 is present in lewy bodies in Parkinson's disease

Koichi Wakabayashi, Simone Engelender, Makoto Yoshimoto, Shoji Tsuji, Christopher A. Ross, Hitoshi Takahashi

Research output: Contribution to journalArticlepeer-review

237 Scopus citations


α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

Original languageEnglish (US)
Pages (from-to)521-523
Number of pages3
JournalAnnals of neurology
Issue number4
StatePublished - 2000

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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