Synphilin-1 is present in lewy bodies in Parkinson's disease

Koichi Wakabayashi; Simone Engelender; Makoto Yoshimoto; Shoji Tsuji; Christopher A. Ross; Hitoshi Takahashi

doi:10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B

Synphilin-1 is present in lewy bodies in Parkinson's disease

Koichi Wakabayashi, Simone Engelender, Makoto Yoshimoto, Shoji Tsuji, Christopher A. Ross, Hitoshi Takahashi

School of Medicine

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Abstract

α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

Original language	English (US)
Pages (from-to)	521-523
Number of pages	3
Journal	Annals of neurology
Volume	47
Issue number	4
DOIs	https://doi.org/10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B
State	Published - 2000

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B

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title = "Synphilin-1 is present in lewy bodies in Parkinson's disease",

abstract = "α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.",

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AU - Wakabayashi, Koichi

AU - Engelender, Simone

AU - Yoshimoto, Makoto

AU - Tsuji, Shoji

AU - Ross, Christopher A.

AU - Takahashi, Hitoshi

PY - 2000

Y1 - 2000

N2 - α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

AB - α-Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α-synuclein gene are responsible for familial forms of PD and α-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with α-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.

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Synphilin-1 is present in lewy bodies in Parkinson's disease

Abstract

ASJC Scopus subject areas

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