Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

E. K. Silbergeld; J. R. Walters

doi:10.1016/0304-3940(79)91491-5

Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

E. K. Silbergeld, J. R. Walters

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27 Scopus citations

Abstract

Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [³H]dopamine. Recently accumulated [³H]dopamine is releasable by 35 mM K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; γ-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10^-4 M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dend-tritic (substantia nigra) and axonal (striatal) terminals.

Original language	English (US)
Pages (from-to)	119-126
Number of pages	8
Journal	Neuroscience Letters
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(79)91491-5
State	Published - Apr 1979
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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title = "Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P",

abstract = "Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [3H]dopamine. Recently accumulated [3H]dopamine is releasable by 35 mM K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; γ-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10-4 M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dend-tritic (substantia nigra) and axonal (striatal) terminals.",

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T2 - Effects of γ-aminobutyric acid and substance P

AU - Silbergeld, E. K.

AU - Walters, J. R.

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N2 - Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [3H]dopamine. Recently accumulated [3H]dopamine is releasable by 35 mM K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; γ-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10-4 M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dend-tritic (substantia nigra) and axonal (striatal) terminals.

AB - Nigral tissue prepared as synaptosomes demonstrates both high and low affinity uptake of [3H]dopamine. Recently accumulated [3H]dopamine is releasable by 35 mM K+. Substance P increases both uptake and release of dopamine by nigral synaptosomes; γ-aminobutyric acid (GABA) inhibits release with no effect on uptake at concentrations less than 10-4 M. In the striatum, substance P inhibits both uptake and release of dopamine. The results support the existence of dopamine-containing terminals in substantia nigra tissue. The differences in response to substance P and GABA found between nigra and striatum may reflect structural differences in dopamine-containing processes in these areas, related to their proposed origin as dend-tritic (substantia nigra) and axonal (striatal) terminals.

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Synaptosomal uptake and release of dopamine in substantia nigra: Effects of γ-aminobutyric acid and substance P

Abstract

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