Synaptic plasticity and phosphorylation

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations


A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity. Recent understanding of synaptic plasticity mechanisms underscores important roles that these synaptic phosphoproteins play in regulating both pre- and post-synaptic functions. This review will focus on key postsynaptic phosphoproteins that have been implicated to play a role in synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)810-832
Number of pages23
JournalPharmacology and Therapeutics
Issue number3
StatePublished - Dec 2006
Externally publishedYes


  • Homeostatic plasticity
  • Long-term depression
  • Long-term potentiation
  • Phosphoproteins
  • Postsynaptic

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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