Symptomatic volunteers in multicenter drug trials

Lino Covi, Ronald S. Lipman, Douglas M. McNair, Thomas Czerlinsky

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


1. 1. Symptomatic volunteers were recruited at two collaborating institutions for antianxiety and antidepressant drug trials. Advertisements were placed for volunteers with significant symptoms of anxiety, depression, or both, and who were not currently in treatment. 2. 2. It was possible to recruit adequate numbers of volunteers who met the numerous criteria for severity of distress, and who were not ruled out by various exclusion criteria, such as medical contraindications, etc. 3. 3. Acceptable homogeneity across the samples at the collaborating institutions was found for demographic characteristics, level of distress, duration of symptoms, etc. 4. 4. Attrition rates for these volunteers were lower than for the typical anxiolytic and antidepressant trials using outpatients. 5. 5. Symptomatic volunteers appear to present a feasible alternative to the increasingly diminishing pool of outpatients.

Original languageEnglish (US)
Pages (from-to)521-533
Number of pages13
JournalProgress in Neuro-Psychopharmacology
Issue number5-6
StatePublished - 1979


  • anxiety
  • clinical drug trials
  • depression
  • symptomatic volunteers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health
  • Pharmacology (medical)


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