TY - JOUR
T1 - Symptomatic volunteers in multicenter drug trials
AU - Covi, Lino
AU - Lipman, Ronald S.
AU - McNair, Douglas M.
AU - Czerlinsky, Thomas
N1 - Funding Information:
K. Smith, Research Associate, Johns Hopkins Medical Psychologist, Boston University School of Medicine, statistical analyses. This work was supported by NIMH
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1979
Y1 - 1979
N2 - 1. 1. Symptomatic volunteers were recruited at two collaborating institutions for antianxiety and antidepressant drug trials. Advertisements were placed for volunteers with significant symptoms of anxiety, depression, or both, and who were not currently in treatment. 2. 2. It was possible to recruit adequate numbers of volunteers who met the numerous criteria for severity of distress, and who were not ruled out by various exclusion criteria, such as medical contraindications, etc. 3. 3. Acceptable homogeneity across the samples at the collaborating institutions was found for demographic characteristics, level of distress, duration of symptoms, etc. 4. 4. Attrition rates for these volunteers were lower than for the typical anxiolytic and antidepressant trials using outpatients. 5. 5. Symptomatic volunteers appear to present a feasible alternative to the increasingly diminishing pool of outpatients.
AB - 1. 1. Symptomatic volunteers were recruited at two collaborating institutions for antianxiety and antidepressant drug trials. Advertisements were placed for volunteers with significant symptoms of anxiety, depression, or both, and who were not currently in treatment. 2. 2. It was possible to recruit adequate numbers of volunteers who met the numerous criteria for severity of distress, and who were not ruled out by various exclusion criteria, such as medical contraindications, etc. 3. 3. Acceptable homogeneity across the samples at the collaborating institutions was found for demographic characteristics, level of distress, duration of symptoms, etc. 4. 4. Attrition rates for these volunteers were lower than for the typical anxiolytic and antidepressant trials using outpatients. 5. 5. Symptomatic volunteers appear to present a feasible alternative to the increasingly diminishing pool of outpatients.
KW - anxiety
KW - clinical drug trials
KW - depression
KW - symptomatic volunteers
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U2 - 10.1016/0364-7722(79)90006-7
DO - 10.1016/0364-7722(79)90006-7
M3 - Article
C2 - 401003
AN - SCOPUS:0018570105
SN - 0364-7722
VL - 3
SP - 521
EP - 533
JO - Progress in Neuro-Psychopharmacology
JF - Progress in Neuro-Psychopharmacology
IS - 5-6
ER -