@article{0651b702092d46b7af9046154798e018,
title = "Swiprosin-1: Its Expression and Diverse Biological Functions",
abstract = "Swiprosin-1/EFhd2 is a Ca2+ binding adapter protein involved in the various cellular functions. Swiprosin-1 is significantly upregulated in a number of pathological conditions of inflammation, neurodegeneration, and cancer. Swiprosin-1 associated with actin and its expression level amplifies the production of proinflammatory mediators and modulates the activation of transcription factor during immune cells activation. This review aims at providing an overview of the expression and function of swiprosin-1/EFhd2 in various pathophysiological conditions. We also discussed the key role of swiprosin-1 in immune cell activation, cell migration, apoptosis, humoral immunity, cancer invasion and metastasis, neuronal transport, and major signaling cascades. J. Cell. Biochem. 119: 150–156, 2018.",
keywords = "IMMUNE CELLS ACTIVATION, PROTEIN KINASE, RECEPTOR SIGNALING, SWIPROSIN-1",
author = "Thylur, {Ramesh P.} and Raghavendra Gowda and Sumita Mishra and Jun, {Chang Duk}",
note = "Funding Information: This work was funded by grants R01-2008-000-20989-0 and R11-2007-007-01002-0 from MEST/KOSEF, and grant 2008-C00265 from Korea Research Foundation. Funding Information: Abbreviations: Arp2/3, Actin-related protein 2/3; BCR, B Cell Receptor; Ca2+, Calcium ion; DNP-HAS, Dinitrophenyl-human serum albumin; ∆PR, Deletant of proline rich; EFhd2, EF-hand domain 2; ERM, Ezrin radixin moesin; EGFR, Epidermal growth factor receptor; GFP, Green fluorescent protein; GTPase, Guanosine triphosphatase; HMC-1, Human mast cells-1; I-kB-α, Inhibitor of kappa B-alpha; IL, Interleukin; IgE, Immunoglobulin E; IgM, Immunoglobulin M; MAP2, Microtubule-associated Protein 2; ∆Cm, Mitochondrial membrane potential; NK, Natural killer; NF-kB, Nuclear Factor Kappa B; NF-AT, Nuclear factor of activated T-cells; PBMA, Peripheral Blood Mononuclear Cell; PKC-βI/h, Protein kinase C-beta/eta; PKC-u, Protein kinase C-thea; PLC-g2, Phospholipase C-gamma-2; PMA, Phorbol myristate acetate; PSD-95, Postsynaptic density protein 95; RANK-L, Receptor Activator of Nuclear Factor Kappa B Ligand; RBL-2H3, Rat Basophilic Leukemia-2H3; Syk, spleen tyrosine kinase; SLP-65, SH2 domain-containing leukocyte adaptor protein of 65 kDa; SH3, SRC Homology 3 Domain; SDF-1α, stromal cell-derived factor 1 alpha; TNF-α, Tumor Necrosis Factor-alpha; VCA, Verprolin, cofilin and acidic; WASP, Wiskott– Aldrich syndrome protein. Conflict of Interest: The authors have no conflict of interest. Grant sponsor: MEST/KOSEF; Grant numbers: R01-2008-000-20989-0, R11-2007-007-01002-0; Grant sponsor: Korea Research Foundation; Grant number: 2008-C00265. *Correspondence to: Dr. Ramesh P. Thylur, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, E-mail: rameshthylur@gmail.com Manuscript Received: 3 June 2017; Manuscript Accepted: 6 June 2017 Accepted manuscript online in Wiley Online Library (wileyonlinelibrary.com): 7 June 2017 DOI 10.1002/jcb.26199 • {\textcopyright} 2017 Wiley Periodicals, Inc. Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2018",
month = jan,
doi = "10.1002/jcb.26199",
language = "English (US)",
volume = "119",
pages = "150--156",
journal = "Journal of cellular biochemistry",
issn = "0730-2312",
publisher = "Wiley-Liss Inc.",
number = "1",
}