Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology

Xiudong Liu; Weiming Xue; Qun Liu; Weiting Yu; Yingli Fu; Xin Xiong; Xiaojun Ma; Quan Yuan

doi:10.1016/j.carbpol.2004.03.011

Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology

Xiudong Liu, Weiming Xue, Qun Liu, Weiting Yu, Yingli Fu, Xin Xiong, Xiaojun Ma, Quan Yuan

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (S_w) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low S_w. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that S_w of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.

Original language	English (US)
Pages (from-to)	459-464
Number of pages	6
Journal	Carbohydrate Polymers
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/j.carbpol.2004.03.011
State	Published - Jul 15 2004
Externally published	Yes

Keywords

Alginate-chitosan microcapsule
External gelation
Internal gelation
Swelling behaviour

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2004.03.011

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title = "Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology",

abstract = "Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (Sw) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low Sw. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that Sw of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.",

keywords = "Alginate-chitosan microcapsule, External gelation, Internal gelation, Swelling behaviour",

author = "Xiudong Liu and Weiming Xue and Qun Liu and Weiting Yu and Yingli Fu and Xin Xiong and Xiaojun Ma and Quan Yuan",

note = "Funding Information: The authors thank the National Natural Science Foundation (People's Republic of China) for the financial support (No: 29906011). The authors also appreciate Associate Professor Qihua He (Center of Analysis, Medical College, Beijing University) for her kindly help in confocal Laser Scanning Microscope.",

year = "2004",

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doi = "10.1016/j.carbpol.2004.03.011",

language = "English (US)",

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AU - Liu, Xiudong

AU - Xue, Weiming

AU - Liu, Qun

AU - Yu, Weiting

AU - Fu, Yingli

AU - Xiong, Xin

AU - Ma, Xiaojun

AU - Yuan, Quan

N1 - Funding Information: The authors thank the National Natural Science Foundation (People's Republic of China) for the financial support (No: 29906011). The authors also appreciate Associate Professor Qihua He (Center of Analysis, Medical College, Beijing University) for her kindly help in confocal Laser Scanning Microscope.

PY - 2004/7/15

Y1 - 2004/7/15

N2 - Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (Sw) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low Sw. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that Sw of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.

AB - Swelling behaviour is one of the important properties for microcapsules made by hydrogels, which always affects the diffusion and release of drugs when the microcapsules are applied in drug delivery systems. In this paper, alginate-chitosan microcapsules were prepared by different technologies called external or internal gelation process respectively. With the volume swelling degree (Sw) as an index, the effect of properties of chitosan on the swelling behaviour of both microcapsules was investigated. It was demonstrated that the microcapsules with low molecular weight and high concentration of chitosan gave rise to low Sw. Considering the need of maintaining drug activity and drug loading, neutral pH and short gelation time were favorable. It was also noticed that Sw of internal gelation microcapsules was lower than that of external gelation microcapsules, which was interpreted by the structure analysis of internal or external gelation Ca-alginate beads with the aid of confocal laser scanning microscope.

KW - Alginate-chitosan microcapsule

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KW - Internal gelation

KW - Swelling behaviour

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Swelling behaviour of alginate-chitosan microcapsules prepared by external gelation or internal gelation technology

Abstract

Keywords

ASJC Scopus subject areas

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