Sweet's syndrome: A cutaneous harbinger of ovarian carcinoma

Amanda Nickles Fader, Abigail Duncan Winder, Samith Sandadi, Robert Debernardo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a condition characterized by fever, neutrophilia, erythematous skin lesions, and a dermal infiltrate consisting predominantly of mature neutrophils on histology. Sweet's syndrome is a reactive phenomenon and should be considered a cutaneous marker of systemic disease, including underlying malignancy. We present a case of a 56-year-old woman who presented with vague abdominal symptoms and a tender, erythematous rash on her extremities. Biopsy of her skin lesions revealed Sweet's syndrome. A work-up for malignancy eventually demonstrated a pelvic mass and carcinomatosis, and a diagnosis of advanced-stage papillary serous ovarian carcinoma was subsequently made. In postmenopausal women who present with Sweet's syndrome, a comprehensive evaluation for malignancy is indicated. In women with a known diagnosis of cancer, Sweet's syndrome may manifest in the detection of persistent or recurrent disease.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalJournal of Gynecologic Oncology
Issue number4
StatePublished - 2012


  • Cutaneous rash
  • Neutrophilia
  • Ovarian neoplasms
  • Paraneoplastic syndrome
  • Sweet's syndrome

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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