Sweating disorders

R. K. Khurana

Research output: Chapter in Book/Report/Conference proceedingChapter


Sweating serves a thermoregulatory function. Both abnormal increase (hyperhidrosis) or decrease (anhidrosis, hypohydrosis) in sweat production can impair quality of life. Structural lesions of the central or peripheral sudomotor pathway may produce localized hyperhydrosis. Generalized hyperhidrosis may be secondary to neuroendocrine disorders, malignancy, infection, or toxins, including prescription drugs, and requires appropriate workup and treatment. Primary hyperhidrosis predominantly affects axillae, palms, and soles; treatment includes topical antiperspirants, systemic pharmacotherapy including anticholinergics, Botox injections, Mira Dry, and surgery. Anhidrosis may be caused by diseases or drugs. Patterns of anhidrosis delineated by thermoregulatory sweat test allow identification of the level of lesion. Recently autobody-mediated and steroid-responsive anhidrosis have been reported.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Number of pages4
ISBN (Electronic)9780128093245
StatePublished - Jan 1 2016
Externally publishedYes


  • Anhidrosis
  • Anticholinergics
  • Botulinum toxin
  • Hyperhidrosis
  • Mira dry
  • Steroid responsiveness
  • Sweat patterns
  • Sympathectomy

ASJC Scopus subject areas

  • General Medicine


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