Survival of penetrating keratoplasty: a claims-based longitudinal analysis

Sumayya Ahmad; Janek Klawe; Canan Asli Utine; Divya Srikumaran; Jose Jimenez; Esen Akpek

doi:10.1016/j.jcjo.2020.07.019

Survival of penetrating keratoplasty: a claims-based longitudinal analysis

Sumayya Ahmad, Janek Klawe, Canan Asli Utine, Divya Srikumaran, Jose Jimenez, Esen Akpek

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. Design: Retrospective longitudinal cohort study using a large commercial insurance database. Participants: Ten million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK. Methods: Kaplan–Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes. Results: Five hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%–82%), 5-year survival was 76% (CI: 70%–80%), and 7-year survival was 73% (CI: 66%–79%). Conclusion: This study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.

Original language	English (US)
Pages (from-to)	12-16
Number of pages	5
Journal	Canadian Journal of Ophthalmology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.jcjo.2020.07.019
State	Published - Feb 2021

ASJC Scopus subject areas

Ophthalmology

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10.1016/j.jcjo.2020.07.019

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@article{e8ed6c896f024ebeb9b5f9f5cc0943c7,

title = "Survival of penetrating keratoplasty: a claims-based longitudinal analysis",

abstract = "Objectives: To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. Design: Retrospective longitudinal cohort study using a large commercial insurance database. Participants: Ten million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK. Methods: Kaplan–Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes. Results: Five hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%–82%), 5-year survival was 76% (CI: 70%–80%), and 7-year survival was 73% (CI: 66%–79%). Conclusion: This study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.",

author = "Sumayya Ahmad and Janek Klawe and Utine, {Canan Asli} and Divya Srikumaran and Jose Jimenez and Esen Akpek",

note = "Funding Information: The authors have no proprietary or commercial interest in any materials discussed in this article. Esen Akpek's employer, Johns Hopkins University, has received institutional grant support to study artificial corneal implantation. Jose Jimenez is an employee of W. L. Gore. Sumayya Ahmad receives research support from the New York Eye and Ear Foundation. Funding Information: Sumayya Ahmad receives research support from the New York Eye and Ear Foundation. Publisher Copyright: {\textcopyright} 2020 Canadian Ophthalmological Society",

year = "2021",

month = feb,

doi = "10.1016/j.jcjo.2020.07.019",

language = "English (US)",

volume = "56",

pages = "12--16",

journal = "Canadian Journal of Ophthalmology",

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publisher = "Elsevier B.V.",

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}

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T1 - Survival of penetrating keratoplasty

T2 - a claims-based longitudinal analysis

AU - Ahmad, Sumayya

AU - Klawe, Janek

AU - Utine, Canan Asli

AU - Srikumaran, Divya

AU - Jimenez, Jose

AU - Akpek, Esen

N1 - Funding Information: The authors have no proprietary or commercial interest in any materials discussed in this article. Esen Akpek's employer, Johns Hopkins University, has received institutional grant support to study artificial corneal implantation. Jose Jimenez is an employee of W. L. Gore. Sumayya Ahmad receives research support from the New York Eye and Ear Foundation. Funding Information: Sumayya Ahmad receives research support from the New York Eye and Ear Foundation. Publisher Copyright: © 2020 Canadian Ophthalmological Society

PY - 2021/2

Y1 - 2021/2

N2 - Objectives: To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. Design: Retrospective longitudinal cohort study using a large commercial insurance database. Participants: Ten million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK. Methods: Kaplan–Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes. Results: Five hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%–82%), 5-year survival was 76% (CI: 70%–80%), and 7-year survival was 73% (CI: 66%–79%). Conclusion: This study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.

AB - Objectives: To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure. Design: Retrospective longitudinal cohort study using a large commercial insurance database. Participants: Ten million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK. Methods: Kaplan–Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes. Results: Five hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%–82%), 5-year survival was 76% (CI: 70%–80%), and 7-year survival was 73% (CI: 66%–79%). Conclusion: This study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.

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Survival of penetrating keratoplasty: a claims-based longitudinal analysis

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