Surgical site infection in orthopedic trauma: A case-control study evaluating risk factors and cost

Rachel V. Thakore, Sarah E. Greenberg, Hanyuan Shi, Alexandra M. Foxx, Elvis L. Francois, Marc A. Prablek, Samuel K. Nwosu, Kristin R. Archer, Jesse M. Ehrenfeld, William T. Obremskey, Manish K. Sethi

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background: With the shift of our healthcare system toward a value-based system of reimbursement, complications such as surgical site infections (SSI) may not be reimbursed. The purpose of our study was to investigate the costs and risk factors of SSI for orthopedic trauma patients. Methods: Through retrospective analysis, 1819 patients with isolated fractures were identified. Of those, 78 patients who developed SSIs were compared to 78 uninfected control patients. Patients were matched by fracture location, type of fracture, duration of surgery, and as close as possible to age, year of surgery, and type of procedure. Costs for treatment during primary hospitalization and initial readmission were determined and potential risk factors were collected from patient charts. A Wilcoxon test was used to compare the overall costs of treatment for case and control patients. Costs were further broken down into professional fees and technical charges for analysis. Risk factors for SSIs were analyzed through a chi-squared analysis. Results: Median cost for treatment for patients with SSIs was $108,782 compared to $57,418 for uninfected patients (p

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalJournal of Clinical Orthopaedics and Trauma
Issue number4
StatePublished - 2015
Externally publishedYes


  • Cost
  • Risk factors
  • Surgical site infection

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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