Surgical methods for inner ear gene delivery in neonatal mouse

Kevin Isgrig, Wade W. Chien

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Inner ear gene therapy offers great potential as a treatment for hearing loss and dizziness. The surgical method used to deliver gene therapy into the inner ear is a critical step in determining the success of inner ear gene therapy. Here we describe two commonly used surgical methods for gene delivery in neonatal mouse inner ear: The round window approach and the posterior semicircular canal approach. Both of these approaches are effective at delivering gene therapy to the neonatal mouse inner ear.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages6
StatePublished - 2019

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Dizziness
  • Gene therapy
  • Hearing loss
  • Inner ear
  • Posterior semicircular canal
  • Round window

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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