Surgical margins in head and neck cancer: A contemporary review

Michael L. Hinni; Alfio Ferlito; Margaret S. Brandwein-Gensler; Robert P. Takes; Carl E. Silver; William H. Westra; Raja R. Seethala; Juan P. Rodrigo; June Corry; Carol R. Bradford; Jennifer L. Hunt; Primož Strojan; Kenneth O. Devaney; Douglas R. Gnepp; Dana M. Hartl; Luiz P. Kowalski; Alessandra Rinaldo; Leon Barnes

doi:10.1002/hed.23110

Surgical margins in head and neck cancer: A contemporary review

Michael L. Hinni, Alfio Ferlito, Margaret S. Brandwein-Gensler, Robert P. Takes, Carl E. Silver, William H. Westra, Raja R. Seethala, Juan P. Rodrigo, June Corry, Carol R. Bradford, Jennifer L. Hunt, Primož Strojan, Kenneth O. Devaney, Douglas R. Gnepp, Dana M. Hartl, Luiz P. Kowalski, Alessandra Rinaldo, Leon Barnes

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.

Original language	English (US)
Pages (from-to)	1362-1370
Number of pages	9
Journal	Head and Neck
Volume	35
Issue number	9
DOIs	https://doi.org/10.1002/hed.23110
State	Published - Sep 2013
Externally published	Yes

Keywords

frozen section
head neck cancer
molecular factors
pattern of invasion
surgical margins

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23110

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Hinni, M. L., Ferlito, A., Brandwein-Gensler, M. S., Takes, R. P., Silver, C. E., Westra, W. H., Seethala, R. R., Rodrigo, J. P., Corry, J., Bradford, C. R., Hunt, J. L., Strojan, P., Devaney, K. O., Gnepp, D. R., Hartl, D. M., Kowalski, L. P., Rinaldo, A., & Barnes, L. (2013). Surgical margins in head and neck cancer: A contemporary review. Head and Neck, 35(9), 1362-1370. https://doi.org/10.1002/hed.23110

Hinni, ML, Ferlito, A, Brandwein-Gensler, MS, Takes, RP, Silver, CE, Westra, WH, Seethala, RR, Rodrigo, JP, Corry, J, Bradford, CR, Hunt, JL, Strojan, P, Devaney, KO, Gnepp, DR, Hartl, DM, Kowalski, LP, Rinaldo, A & Barnes, L 2013, 'Surgical margins in head and neck cancer: A contemporary review', Head and Neck, vol. 35, no. 9, pp. 1362-1370. https://doi.org/10.1002/hed.23110

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abstract = "Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as {"}molecular margins{"} and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.",

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author = "Hinni, {Michael L.} and Alfio Ferlito and Brandwein-Gensler, {Margaret S.} and Takes, {Robert P.} and Silver, {Carl E.} and Westra, {William H.} and Seethala, {Raja R.} and Rodrigo, {Juan P.} and June Corry and Bradford, {Carol R.} and Hunt, {Jennifer L.} and Primo{\v z} Strojan and Devaney, {Kenneth O.} and Gnepp, {Douglas R.} and Hartl, {Dana M.} and Kowalski, {Luiz P.} and Alessandra Rinaldo and Leon Barnes",

year = "2013",

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AU - Westra, William H.

AU - Seethala, Raja R.

AU - Rodrigo, Juan P.

AU - Corry, June

AU - Bradford, Carol R.

AU - Hunt, Jennifer L.

AU - Strojan, Primož

AU - Devaney, Kenneth O.

AU - Gnepp, Douglas R.

AU - Hartl, Dana M.

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AU - Rinaldo, Alessandra

AU - Barnes, Leon

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AB - Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as "molecular margins" and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection.

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Surgical margins in head and neck cancer: A contemporary review

Abstract

Keywords

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