TY - JOUR
T1 - Surgical management of hereditary colorectal cancer
T2 - Surgery based on molecular analysis and family history
AU - Perea García, José
AU - Justo, I.
AU - Álvaro, E.
AU - Lomas, M.
AU - Díaz Tasende, J.
AU - Marín, J. C.
AU - Franco, A.
AU - Colina, F.
AU - Rodríguez, Y.
AU - Martínez, J.
AU - Robles, L.
AU - Urioste, M.
AU - Hidalgo, M.
PY - 2009/8
Y1 - 2009/8
N2 - The importance of colorectal cancer (CRC) is increasing. A proportion show a hereditary component, as in Lynch syndrome and Familial Adenomatous Polyposis, and a recently defined entity as well, namely, Familial Colorectal Cancer type X. The high probability to develop CRC in these groups may, at the time of recognition, change surgical management, including its timing or even the surgical technique. In some cases prophylactic surgery can play an important role. The possibility of using tools that allow recognition of the aforementioned syndromes, including microsatellite instability, immunohistochemistry for DNA mismatch repair system proteins, and especially their mutations, is on the basis of therapeutic strategies that differ from those employed in sporadic CRC cases.
AB - The importance of colorectal cancer (CRC) is increasing. A proportion show a hereditary component, as in Lynch syndrome and Familial Adenomatous Polyposis, and a recently defined entity as well, namely, Familial Colorectal Cancer type X. The high probability to develop CRC in these groups may, at the time of recognition, change surgical management, including its timing or even the surgical technique. In some cases prophylactic surgery can play an important role. The possibility of using tools that allow recognition of the aforementioned syndromes, including microsatellite instability, immunohistochemistry for DNA mismatch repair system proteins, and especially their mutations, is on the basis of therapeutic strategies that differ from those employed in sporadic CRC cases.
KW - Colorectal cancer
KW - Familial adenomatous polyposis
KW - Familial colorectal cancer type X
KW - Lynch syndrome
KW - Surgery
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UR - http://www.scopus.com/inward/citedby.url?scp=74849117329&partnerID=8YFLogxK
M3 - Article
C2 - 19785492
AN - SCOPUS:74849117329
SN - 1130-0108
VL - 101
SP - 536
EP - 540
JO - Revista Espanola de Enfermedades Digestivas
JF - Revista Espanola de Enfermedades Digestivas
IS - 8
ER -