TY - JOUR
T1 - Surface mobility of postsynaptic AMPARs tunes synaptic transmission
AU - Heine, Martin
AU - Groc, Laurent
AU - Frischknecht, Renato
AU - Béïque, Jean Claude
AU - Lounis, Brahim
AU - Rumbaugh, Gavin
AU - Huganir, Richard L.
AU - Cognet, Laurent
AU - Choquet, Daniel
PY - 2008/4/11
Y1 - 2008/4/11
N2 - AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.
AB - AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.
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U2 - 10.1126/science.1152089
DO - 10.1126/science.1152089
M3 - Article
C2 - 18403705
AN - SCOPUS:42049089558
SN - 0036-8075
VL - 320
SP - 201
EP - 205
JO - Science
JF - Science
IS - 5873
ER -