Surface mobility of postsynaptic AMPARs tunes synaptic transmission

Martin Heine; Laurent Groc; Renato Frischknecht; Jean Claude Béïque; Brahim Lounis; Gavin Rumbaugh; Richard L. Huganir; Laurent Cognet; Daniel Choquet

doi:10.1126/science.1152089

Surface mobility of postsynaptic AMPARs tunes synaptic transmission

Martin Heine, Laurent Groc, Renato Frischknecht, Jean Claude Béïque, Brahim Lounis, Gavin Rumbaugh, Richard L. Huganir, Laurent Cognet, Daniel Choquet

School of Medicine

Research output: Contribution to journal › Article › peer-review

340 Scopus citations

Abstract

AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	Science
Volume	320
Issue number	5873
DOIs	https://doi.org/10.1126/science.1152089
State	Published - Apr 11 2008

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abstract = "AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with na{\"i}ve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.",

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AU - Heine, Martin

AU - Groc, Laurent

AU - Frischknecht, Renato

AU - Béïque, Jean Claude

AU - Lounis, Brahim

AU - Rumbaugh, Gavin

AU - Huganir, Richard L.

AU - Cognet, Laurent

AU - Choquet, Daniel

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AB - AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naïve functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.

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Surface mobility of postsynaptic AMPARs tunes synaptic transmission

Abstract

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