Suprofen-Induced Transient Flank Pain and Renal Failure

Sidney M. Wolfe, Carol L. Ellis, Joseph J. Anisko, Robert Temple

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: The Food and Drug Administration has received reports of 308 cases of acute renal injury in patients taking the nonsteroidal antiinflammatory drug suprofen (Suprol, McNeil) (Harter J [FDA]: personal communication). The typical case involves the onset, usually within hours of the first or second dose, of severe flank pain, often radiating to the abdomen or groin, sometimes accompanied by nausea and vomiting, usually accompanied by azotemia and hematuria. In an analysis of the first 51 cases received by the FDA,1 the data shown in Table 1 were reported (18 of the 51 patients [35 percent] were hospitalized). Of the….

Original languageEnglish (US)
Pages (from-to)1025-1026
Number of pages2
JournalNew England Journal of Medicine
Issue number16
StatePublished - Apr 16 1987

ASJC Scopus subject areas

  • General Medicine


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