[3H]Clonidine binds to two rat CNS α-receptor sites, with KD values of 0.5 nM and 3.0 nM. These sites can be examined in isolation from each other. α-Agonists are more potent at the high affinity site, while the converse is true for α-antagonists. The regional distribution in rat CNS for high affinity and low affinity [3H]clonidine binding is different. In the cerebral cortex, 6-hydroxydopamine (6-OHDA) treatment doubles the number of high affinity sites, but does not affect the number of low affinity sites. Throughout the brain, 6-OHDA treatment increases high affinity binding much more than low affinity binding, except in the pons and medulla, where 6-OHDA did not change high affinity [3H]clonidine binding.
|Original language||English (US)|
|Number of pages||5|
|Journal||Advances in the Biosciences|
|State||Published - Dec 1 1979|