3H-apomorphine interactions with dopamine receptors in calf brain

Leon Thal, Ian Creese, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number3
StatePublished - Jun 1 1978


  • Dopamine receptor
  • H-Apomorphine binding
  • H-Dopamine binding
  • H-Haloperidol binding
  • Neuroleptic

ASJC Scopus subject areas

  • Pharmacology


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