3H-apomorphine interactions with dopamine receptors in calf brain

Leon Thal; Ian Creese; Solomon H. Snyder

doi:10.1016/0014-2999(78)90105-X

³H-apomorphine interactions with dopamine receptors in calf brain

Leon Thal, Ian Creese, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

³H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, ³H-apomorphine interacts with receptors in a manner more like ³H-dopamine than ³H-haloperidol. These properties of ³H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

Original language	English (US)
Pages (from-to)	295-299
Number of pages	5
Journal	European Journal of Pharmacology
Volume	49
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(78)90105-X
State	Published - Jun 1 1978

Keywords

Dopamine receptor
H-Apomorphine binding
H-Dopamine binding
H-Haloperidol binding
Neuroleptic

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(78)90105-X

Cite this

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title = "3H-apomorphine interactions with dopamine receptors in calf brain",

abstract = "3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently {"}pure{"} agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.",

keywords = "Dopamine receptor, H-Apomorphine binding, H-Dopamine binding, H-Haloperidol binding, Neuroleptic",

author = "Leon Thal and Ian Creese and Snyder, {Solomon H.}",

note = "Funding Information: We thank Timothy Proaser for excellent technical assistance and Pamela Morgan for manuscript preparation. This research was supported by USPHS grants MH-18501 to SHS, and by grants of the Mcknight and John A. Hartford Foundation, Inc. and The Benevolent Foundation of Scottish Rite Freemasonry, Northern Jurisdiction, U.S.A.",

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AU - Creese, Ian

AU - Snyder, Solomon H.

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PY - 1978/6/1

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