Sumoylation promotes optimal apc/c activation and timely anaphase

Christine C. Lee, Bing Li, Hongtao Yu, Michael J. Matunis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin E3 ligase that functions as the gatekeeper to mitotic exit. APC/C activity is controlled by an interplay of multiple pathways during mitosis, including the spindle assembly checkpoint (SAC), that are not yet fully understood. Here, we show that sumoylation of the APC4 subunit of the APC/C peaks during mitosis and is critical for timely APC/C activation and anaphase onset. We have also identified a functionally important SUMO interacting motif in the cullin-homology domain of APC2 located near the APC4 sumoylation sites and APC/C catalytic core. Our findings provide evidence of an important regulatory role for SUMO modification and binding in affecting APC/C activation and mitotic exit.

Original languageEnglish (US)
Article numbere29539
StatePublished - Mar 8 2018

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


Dive into the research topics of 'Sumoylation promotes optimal apc/c activation and timely anaphase'. Together they form a unique fingerprint.

Cite this