TY - JOUR
T1 - Sugar, fat, and protein
T2 - New insights into what T cells crave
AU - Delgoffe, Greg M.
AU - Powell, Jonathan D.
N1 - Funding Information:
This work was supported in part by National Institutes of Health, NIAID (grant nos. R01AI077610 and R01AI091481 ) (JDP).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - T cell activation and differentiation is a complex process that has evolved beyond the two-signal model to a number of varied and opposing inputs that must be interpreted to make a cell fate decision. While stimulation through the TCR, costimulatory, and cytokine receptors is required, metabolic signaling has emerged not only as an activation signal, but also one that can influence and shape differentiation. Recent findings have revealed unappreciated roles for glucose, fatty acids, and salt in the function of many T cell subsets. In this review, we will highlight the latest advances in the burgeoning field of immunometabolism, focusing on how the menu of T cell fuels has expanded.
AB - T cell activation and differentiation is a complex process that has evolved beyond the two-signal model to a number of varied and opposing inputs that must be interpreted to make a cell fate decision. While stimulation through the TCR, costimulatory, and cytokine receptors is required, metabolic signaling has emerged not only as an activation signal, but also one that can influence and shape differentiation. Recent findings have revealed unappreciated roles for glucose, fatty acids, and salt in the function of many T cell subsets. In this review, we will highlight the latest advances in the burgeoning field of immunometabolism, focusing on how the menu of T cell fuels has expanded.
UR - http://www.scopus.com/inward/record.url?scp=84922362257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922362257&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2015.01.015
DO - 10.1016/j.coi.2015.01.015
M3 - Review article
C2 - 25665466
AN - SCOPUS:84922362257
SN - 0952-7915
VL - 33
SP - 49
EP - 54
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -