TY - JOUR
T1 - Successful use of cyclosporine as treatment for eosinophilic cystitis
T2 - A case report
AU - Aleem, Sohaib
AU - Kumar, Bharat
AU - Fasano, Mary Beth
AU - Takacs, Elizabeth
AU - Azar, Antoine Emile
N1 - Publisher Copyright:
© 2016 Aleem et al.
PY - 2016/7/8
Y1 - 2016/7/8
N2 - Background: Eosinophilic cystitis is a rare inflammatory disorder characterized by eosinophilic infiltration of all layers of the urinary bladder wall. Due to lack of consensus and potential for side effect from various therapeutic options, treatment of the disease is often challenging. Case presentation: A 64-year old woman with hypertensive nephropathy resulting in stage III chronic kidney disease, obstructive sleep apnea, and obstructive lung disease presented with a 4 month history of dysuria, urgency, frequency, and persistent hematuria. Based on eosinophilic infiltration on bladder wall biopsy in the absence of any evidence of infection, malignancy, or immune disorder, she was diagnosed with eosinophilic cystitis. Despite multiple medication regimens, her symptoms persisted, requiring high-dose prednisone with steroid-related side effects. After four months, she was started on cyclosporine, which led to symptomatic improvement and reduction in prednisone dosage. At that time, repeat urine cytology and cystoscopy did not reveal friable tissues or eosinophiluria. Conclusion: This case illustrates the utility of using cyclosporine to treat eosinophilic cystitis in adult patient with multiple comorbid conditions.
AB - Background: Eosinophilic cystitis is a rare inflammatory disorder characterized by eosinophilic infiltration of all layers of the urinary bladder wall. Due to lack of consensus and potential for side effect from various therapeutic options, treatment of the disease is often challenging. Case presentation: A 64-year old woman with hypertensive nephropathy resulting in stage III chronic kidney disease, obstructive sleep apnea, and obstructive lung disease presented with a 4 month history of dysuria, urgency, frequency, and persistent hematuria. Based on eosinophilic infiltration on bladder wall biopsy in the absence of any evidence of infection, malignancy, or immune disorder, she was diagnosed with eosinophilic cystitis. Despite multiple medication regimens, her symptoms persisted, requiring high-dose prednisone with steroid-related side effects. After four months, she was started on cyclosporine, which led to symptomatic improvement and reduction in prednisone dosage. At that time, repeat urine cytology and cystoscopy did not reveal friable tissues or eosinophiluria. Conclusion: This case illustrates the utility of using cyclosporine to treat eosinophilic cystitis in adult patient with multiple comorbid conditions.
KW - Cyclosporine
KW - Eosinophilic cystitis
KW - Steroids
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U2 - 10.1186/s40413-016-0113-4
DO - 10.1186/s40413-016-0113-4
M3 - Article
C2 - 27458500
AN - SCOPUS:84979653186
SN - 1939-4551
VL - 9
JO - World Allergy Organization Journal
JF - World Allergy Organization Journal
IS - 1
M1 - 22
ER -