Successful Use of an Autologous Homologous Skin Construct for the Management of Acute Surgical and Traumatic Wounds: A Clinical Experience in Two Patients

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Autologous homologous skin construct promises to regenerate appendage-bearing skin using a small ellipse of full-thickness tissue that is harvested from the patient and sent to the manufacturer for processing. With so many surgical treatments available for wound management, data on the value and efficacy of this product will play a particularly important role in determining its indications for use. Objective. It was hypothesized that the AHSC would be most beneficial in patients who are unable to undergo conventional reconstruction with skin grafts or flaps. The experience of successfully using the product in 2 patients with a relative contraindication to skin grafting is described. Case Reports. The first patient had a history of a collagen genetic mutation and presented after traumatic degloving of the lower extremity, which was initially treated with a dermal regeneration template. The second patient had a previous history of failed skin grafting of a surgical wound following excision of a recurrent nonmelanoma skin cancer of the back. The patients were followed to the end point of complete wound healing at 4 months (case 1) and 5 weeks (case 2). Conclusions. Although more rigorous medical and financial analysis of this treatment will be necessary, these early data suggest a potential role for the AHSC in the management of wounds for patients who cannot receive conventional techniques for wound coverage.

Original languageEnglish (US)
Pages (from-to)E74-E77
JournalWounds
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2022

Keywords

  • dermal appendage
  • flap
  • skin graft
  • skin regeneration
  • tissue engineering

ASJC Scopus subject areas

  • General Medicine

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