Successful Treatment of Human Genital Herpes Infections With 2-Deoxy-D-glucose

Herbert A. Blough, Robert L. Giuntoli

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48 Scopus citations


Thirty-six women with genital herpes infections (proved by virological or cytological means) were treated in a double-blind placebo-controlled study with the glucose analogue 2-deoxy-D-glucose for a three-week period. In initial mucocutaneous cases, 89% were cured, with two recurrences after 24 months; in the case of recurrent or secondary infections, 90% had a notable improvement manifested by no or less-frequent recurrences, fewer lesions, or shortened duration of symptoms. In initial infections, discomfort cleared within 12 to 72 hours of therapy; 90% of the patients were asymptomatic within four days. In both cases, virus shedding was notably reduced by 2-deoxy-D-glucose. Concomitant controls treated with placebos failed to respond within this time frame. The use of 2-deoxy-D-glucose provides a simple and unique approach to the treatment of genital herpesvirus infections. (JAMA 241:2798-2801, 1979).

Original languageEnglish (US)
Pages (from-to)2798-2801
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number26
StatePublished - Jun 29 1979

ASJC Scopus subject areas

  • Medicine(all)


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