X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19+ B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676.
- Acute myeloid leukemia
- Stem cell transplantation
- X-linked agammaglobulinemia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health