Successful aging in a 70-year-old man with down syndrome: A case study

Sharon J. Krinsky-McHale; Darlynne A. Devenny; Hong Gu; Edmund C. Jenkins; Phyllis Kittler; Vundavalli V. Murty; Nicole Schupf; Luigi Scotto; Benjamin Tycko; Tiina K. Urv; Lingling Ye; Warren B. Zigman; Wayne Silverman

doi:10.1352/2008.46:215-228

Successful aging in a 70-year-old man with down syndrome: A case study

Sharon J. Krinsky-McHale, Darlynne A. Devenny, Hong Gu, Edmund C. Jenkins, Phyllis Kittler, Vundavalli V. Murty, Nicole Schupf, Luigi Scotto, Benjamin Tycko, Tiina K. Urv, Lingling Ye, Warren B. Zigman, Wayne Silverman

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Abstract

The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.

Original language	English (US)
Pages (from-to)	215-228
Number of pages	14
Journal	Intellectual and Developmental Disabilities
Volume	46
Issue number	3
DOIs	https://doi.org/10.1352/2008.46:215-228
State	Published - Jun 2008
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Education
Developmental and Educational Psychology
Community and Home Care
Psychiatry and Mental health

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abstract = "The authors present a case study of a 70-year-old man with Down syndrome ({"}Mr. C.{"}) who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.",

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AU - Devenny, Darlynne A.

AU - Gu, Hong

AU - Jenkins, Edmund C.

AU - Kittler, Phyllis

AU - Murty, Vundavalli V.

AU - Schupf, Nicole

AU - Scotto, Luigi

AU - Tycko, Benjamin

AU - Urv, Tiina K.

AU - Ye, Lingling

AU - Zigman, Warren B.

AU - Silverman, Wayne

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Successful aging in a 70-year-old man with down syndrome: A case study

Abstract

ASJC Scopus subject areas

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