Successful aging in a 70-year-old man with down syndrome: A case study

Sharon J. Krinsky-McHale, Darlynne A. Devenny, Hong Gu, Edmund C. Jenkins, Phyllis Kittler, Vundavalli V. Murty, Nicole Schupf, Luigi Scotto, Benjamin Tycko, Tiina K. Urv, Lingling Ye, Warren B. Zigman, Wayne Silverman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The authors present a case study of a 70-year-old man with Down syndrome ("Mr. C.") who they followed for 16 years and who does not exhibit declines in cognitive or functional capacities indicative of dementia, despite having well-documented, complete trisomy 21. The authors describe the age-associated changes that occurred over 16 years as well as provide detailed information regarding Mr. C.'s health and genetic status. To further emphasize Mr. C.'s successful aging, the authors compared his longitudinal performance profile with that of 2 peers of comparable level of intellectual functioning: 1 similar-aged man with clinical Alzheimer's disease and a younger man who was healthy. The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome.

Original languageEnglish (US)
Pages (from-to)215-228
Number of pages14
JournalIntellectual and Developmental Disabilities
Issue number3
StatePublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Education
  • Developmental and Educational Psychology
  • Community and Home Care
  • Psychiatry and Mental health


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