TY - JOUR
T1 - Subtypes of functional brain connectivity as early markers of neurodegeneration in Alzheimer’s disease
AU - For the Alzheimer’s Disease Neuroimaging Initiative
AU - and the Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer’s Disease Program
AU - Orban, Pierre
AU - Tam, Angela
AU - Urchs, Sebastian
AU - Savard, Melissa
AU - Madjar, Cécile
AU - Badhwar, Aman Preet
AU - Dansereau, Christian
AU - Vogel, Jacob
AU - Schmuel, Amir
AU - Dagher, Alain
AU - Villeneuve, Sylvia
AU - Poirier, Judes
AU - Rosa-Neto, Pedro
AU - Breitner, John
AU - Bellec, Pierre
N1 - Publisher Copyright:
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017/9/28
Y1 - 2017/9/28
N2 - Highlights Reliable functional brain network subtypes accompany cognitive impairment in ADSymptom-related subtypes exist in the default-mode, limbic and salience networksA limbic subtype is associated with a familial risk of AD in healthy older adultsLimbic subtypes also associate with beta amyloid deposition and ApoE4 In Brief We found reliable subtypes of functional brain connectivity networks in older adults, associated with AD-related clinical symptoms in patients as well as several AD risk factors/biomarkers in asymptomatic individuals. Summary The heterogeneity of brain degeneration has not been investigated yet for functional brain network connectivity, a promising biomarker of Alzheimer’s disease. We coupled cluster analysis with resting-state functional magnetic resonance imaging to discover connectivity subtypes in healthy older adults and patients with cognitive disorders related to Alzheimer’s disease, noting associations between subtypes and cognitive symptoms in the default-mode, limbic and salience networks. In an independent asymptomatic cohort with a family history of Alzheimer’s dementia, the connectivity subtypes had good test-retest reliability across all tested networks. We found that a limbic subtype was overrepresented in these individuals, which was previously associated with symptoms. Other limbic subtypes showed associations with cerebrospinal fluid Aβ1-42 levels and ApoE4 genotype. Our results demonstrate the existence of reliable subtypes of functional brain networks in older adults and support future investigations in limbic connectivity subtypes as early biomarkers of Alzheimer’s degeneration.
AB - Highlights Reliable functional brain network subtypes accompany cognitive impairment in ADSymptom-related subtypes exist in the default-mode, limbic and salience networksA limbic subtype is associated with a familial risk of AD in healthy older adultsLimbic subtypes also associate with beta amyloid deposition and ApoE4 In Brief We found reliable subtypes of functional brain connectivity networks in older adults, associated with AD-related clinical symptoms in patients as well as several AD risk factors/biomarkers in asymptomatic individuals. Summary The heterogeneity of brain degeneration has not been investigated yet for functional brain network connectivity, a promising biomarker of Alzheimer’s disease. We coupled cluster analysis with resting-state functional magnetic resonance imaging to discover connectivity subtypes in healthy older adults and patients with cognitive disorders related to Alzheimer’s disease, noting associations between subtypes and cognitive symptoms in the default-mode, limbic and salience networks. In an independent asymptomatic cohort with a family history of Alzheimer’s dementia, the connectivity subtypes had good test-retest reliability across all tested networks. We found that a limbic subtype was overrepresented in these individuals, which was previously associated with symptoms. Other limbic subtypes showed associations with cerebrospinal fluid Aβ1-42 levels and ApoE4 genotype. Our results demonstrate the existence of reliable subtypes of functional brain networks in older adults and support future investigations in limbic connectivity subtypes as early biomarkers of Alzheimer’s degeneration.
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U2 - 10.1101/195164
DO - 10.1101/195164
M3 - Article
AN - SCOPUS:85094413949
SN - 0309-1708
JO - Unknown Journal
JF - Unknown Journal
ER -