Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

Lindsey Dzierozynski; Jessica Queen; Cynthia L. Sears

doi:10.1016/j.chom.2023.09.007

Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

Lindsey Dzierozynski, Jessica Queen, Cynthia L. Sears

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.

Original language	English (US)
Pages (from-to)	1569-1573
Number of pages	5
Journal	Cell Host and Microbe
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/j.chom.2023.09.007
State	Published - Oct 11 2023

Keywords

cancer
colon
colorectal cancer
gut
host genes
inflammatory bowel disease
inter-kingdom interactions
microbial evolution
microbiota
mutualism

ASJC Scopus subject areas

Virology
Parasitology
Microbiology

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10.1016/j.chom.2023.09.007

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title = "Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology",

abstract = "Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.",

keywords = "cancer, colon, colorectal cancer, gut, host genes, inflammatory bowel disease, inter-kingdom interactions, microbial evolution, microbiota, mutualism",

author = "Lindsey Dzierozynski and Jessica Queen and Sears, {Cynthia L.}",

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AU - Queen, Jessica

AU - Sears, Cynthia L.

PY - 2023/10/11

Y1 - 2023/10/11

N2 - Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.

AB - Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This commentary discusses current literature supporting host genetic influences on resident species and pathogenic microbes. Mechanistic experimental studies are warranted to understand host gene-microbiome interplay.

KW - cancer

KW - colon

KW - colorectal cancer

KW - gut

KW - host genes

KW - inflammatory bowel disease

KW - inter-kingdom interactions

KW - microbial evolution

KW - microbiota

KW - mutualism

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Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology

Abstract

Keywords

ASJC Scopus subject areas

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