Subthalamic nucleus involvement in children: A neuroimaging pattern-recognition approach

Thangamadhan Bosemani, Cristina Anghelescu, Eugen Boltshauser, Alexander H. Hoon, Phillip L. Pearl, Dana Craiu, Michael V. Johnston, Thierry A.G.M. Huisman, Andrea Poretti

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


A neuroimaging-based pattern-recognition approach has been shown to be very helpful in the diagnosis of a wide range of pediatric central nervous system diseases. Few disorders may selectively affect the subthalamic nucleus in children including Leigh syndrome, succinic semialdehyde dehydrogenase deficiency, kernicterus, chronic end-stage liver failure and near total hypoxic-ischemic injury in the full-term neonates. The consideration of the constellation of clinical history and findings as well as additional neuroimaging findings should allow planning the appropriate diagnostic tests to make the correct diagnosis in children with involvement of the subthalamic nucleus.

Original languageEnglish (US)
Pages (from-to)249-256
Number of pages8
JournalEuropean Journal of Paediatric Neurology
Issue number3
StatePublished - May 2014


  • Children
  • Magnetic resonance imaging
  • Pattern-recognition approach
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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