TY - JOUR
T1 - Substance K and substance P as possible endogenous substrates of angiotensin converting enzyme in the brain
AU - Thiele, Elizabeth A.
AU - Strittmatter, Stephen M.
AU - Snyder, Solomon H.
N1 - Funding Information:
This work was supported by training grant GM-07309 to S.M.S. and by USPHS grants DA-00266, NS-16375 and Research Scientist Award DA-00074 to S.H.S.
PY - 1985/4/16
Y1 - 1985/4/16
N2 - In the brain angiotensin converting enzyme is highly localized to a striatonigral pathway, which contains no endogenous angiotensin. Substance P, also localized to a striatonigral pathway, is degraded by ACE via two different pathways. The lung and striatal isozymes of angiotensin converting enzyme exhibit differential cleavage of substance P, with lung preferring an initial tripeptide cleavage, and striatum an initial dipeptide cleavage. Substance K is degraded by the striatal isozyme but is not cleaved by the lung isozyme. Substance P 5-11 is not cleaved by either form of angiotensin converting enzyme.
AB - In the brain angiotensin converting enzyme is highly localized to a striatonigral pathway, which contains no endogenous angiotensin. Substance P, also localized to a striatonigral pathway, is degraded by ACE via two different pathways. The lung and striatal isozymes of angiotensin converting enzyme exhibit differential cleavage of substance P, with lung preferring an initial tripeptide cleavage, and striatum an initial dipeptide cleavage. Substance K is degraded by the striatal isozyme but is not cleaved by the lung isozyme. Substance P 5-11 is not cleaved by either form of angiotensin converting enzyme.
UR - http://www.scopus.com/inward/record.url?scp=0022378632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022378632&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(85)91681-X
DO - 10.1016/0006-291X(85)91681-X
M3 - Article
C2 - 2580530
AN - SCOPUS:0022378632
SN - 0006-291X
VL - 128
SP - 317
EP - 324
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -