Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages

R. B. Zeidler; J. A. Flynn; J. C. Arnold; N. S. Conley

doi:10.1007/BF00915841

Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages

R. B. Zeidler, J. A. Flynn, J. C. Arnold, N. S. Conley

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subpopulations generate superoxide anions, although to varying degrees. Band 3 cells are the most active, while band 1 cells are the least active. The amount of superoxide anions released in a mixed population of bands 1, 2, and 3 cells was less than the sum of that produced from each band assayed separately. Band 1 cells were found to inhibit by 47% the production of superoxide anions by band 3 cells. Conditioned medium from band 1 cells contains a heat-sensitive, nondialyzable, soluble factor responsible for this inhibition.

Original language	English (US)
Pages (from-to)	371-379
Number of pages	9
Journal	Inflammation
Volume	11
Issue number	3
DOIs	https://doi.org/10.1007/BF00915841
State	Published - Sep 1 1987

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages",

abstract = "Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subpopulations generate superoxide anions, although to varying degrees. Band 3 cells are the most active, while band 1 cells are the least active. The amount of superoxide anions released in a mixed population of bands 1, 2, and 3 cells was less than the sum of that produced from each band assayed separately. Band 1 cells were found to inhibit by 47% the production of superoxide anions by band 3 cells. Conditioned medium from band 1 cells contains a heat-sensitive, nondialyzable, soluble factor responsible for this inhibition.",

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T1 - Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages

AU - Zeidler, R. B.

AU - Flynn, J. A.

AU - Arnold, J. C.

AU - Conley, N. S.

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N2 - Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subpopulations generate superoxide anions, although to varying degrees. Band 3 cells are the most active, while band 1 cells are the least active. The amount of superoxide anions released in a mixed population of bands 1, 2, and 3 cells was less than the sum of that produced from each band assayed separately. Band 1 cells were found to inhibit by 47% the production of superoxide anions by band 3 cells. Conditioned medium from band 1 cells contains a heat-sensitive, nondialyzable, soluble factor responsible for this inhibition.

AB - Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subpopulations generate superoxide anions, although to varying degrees. Band 3 cells are the most active, while band 1 cells are the least active. The amount of superoxide anions released in a mixed population of bands 1, 2, and 3 cells was less than the sum of that produced from each band assayed separately. Band 1 cells were found to inhibit by 47% the production of superoxide anions by band 3 cells. Conditioned medium from band 1 cells contains a heat-sensitive, nondialyzable, soluble factor responsible for this inhibition.

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Subpopulation of alveolar macrophages inhibits superoxide anion production by macrophages

Abstract

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