Subcortical brain atrophy persists even in HAART-regulated HIV disease

James T. Becker; Joanne Sanders; Sarah K. Madsen; Ann Ragin; Lawrence Kingsley; Victoria Maruca; Bruce Cohen; Karl Goodkin; Eileen Martin; Eric N. Miller; Ned Sacktor; Jeffery R. Alger; Peter B. Barker; Priyanka Saharan; Owen T. Carmichael; Paul M. Thompson

doi:10.1007/s11682-011-9113-8

Subcortical brain atrophy persists even in HAART-regulated HIV disease

James T. Becker, Joanne Sanders, Sarah K. Madsen, Ann Ragin, Lawrence Kingsley, Victoria Maruca, Bruce Cohen, Karl Goodkin, Eileen Martin, Eric N. Miller, Ned Sacktor, Jeffery R. Alger, Peter B. Barker, Priyanka Saharan, Owen T. Carmichael, Paul M. Thompson

School of Medicine

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.

Original language	English (US)
Pages (from-to)	77-85
Number of pages	9
Journal	Brain Imaging and Behavior
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s11682-011-9113-8
State	Published - Jun 2011

Keywords

Basal ganglia
Gray matter
HIV
MRI

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Cognitive Neuroscience
Radiology Nuclear Medicine and imaging
Behavioral Neuroscience

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10.1007/s11682-011-9113-8

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Becker, J. T., Sanders, J., Madsen, S. K., Ragin, A., Kingsley, L., Maruca, V., Cohen, B., Goodkin, K., Martin, E., Miller, E. N., Sacktor, N., Alger, J. R., Barker, P. B., Saharan, P., Carmichael, O. T., & Thompson, P. M. (2011). Subcortical brain atrophy persists even in HAART-regulated HIV disease. Brain Imaging and Behavior, 5(2), 77-85. https://doi.org/10.1007/s11682-011-9113-8

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title = "Subcortical brain atrophy persists even in HAART-regulated HIV disease",

abstract = "The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.",

keywords = "Basal ganglia, Gray matter, HIV, MRI",

author = "Becker, {James T.} and Joanne Sanders and Madsen, {Sarah K.} and Ann Ragin and Lawrence Kingsley and Victoria Maruca and Bruce Cohen and Karl Goodkin and Eileen Martin and Miller, {Eric N.} and Ned Sacktor and Alger, {Jeffery R.} and Barker, {Peter B.} and Priyanka Saharan and Carmichael, {Owen T.} and Thompson, {Paul M.}",

note = "Funding Information: Acknowledgements The authors are grateful to the participants and the staff of the Multicenter AIDS Cohort Study for the additional time and effort that they contributed towards the successful completion of this project. This study was supported in part by funds from the National Institute for Allergy and Infectious Diseases to the collaborating MACS sites: UO1-AI-35042, 5-MO1-RR-00052 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041. The NP Working Group is grateful to the Executive Advisory Committee of the MACS, and particularly Dr. Roger Detels, for providing the funding of this project. SM, PS, and PT are supported in part by EB008281 and EB007813 (to PT). The funding agencies had no role in the design, acquisition, analysis or reporting the findings of this research. The authors would like to thank Wei Wang for running the FDS code.",

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doi = "10.1007/s11682-011-9113-8",

language = "English (US)",

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AU - Becker, James T.

AU - Sanders, Joanne

AU - Madsen, Sarah K.

AU - Ragin, Ann

AU - Kingsley, Lawrence

AU - Maruca, Victoria

AU - Cohen, Bruce

AU - Goodkin, Karl

AU - Martin, Eileen

AU - Miller, Eric N.

AU - Sacktor, Ned

AU - Alger, Jeffery R.

AU - Barker, Peter B.

AU - Saharan, Priyanka

AU - Carmichael, Owen T.

AU - Thompson, Paul M.

N1 - Funding Information: Acknowledgements The authors are grateful to the participants and the staff of the Multicenter AIDS Cohort Study for the additional time and effort that they contributed towards the successful completion of this project. This study was supported in part by funds from the National Institute for Allergy and Infectious Diseases to the collaborating MACS sites: UO1-AI-35042, 5-MO1-RR-00052 (GCRC), UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, UO1-AI-35041. The NP Working Group is grateful to the Executive Advisory Committee of the MACS, and particularly Dr. Roger Detels, for providing the funding of this project. SM, PS, and PT are supported in part by EB008281 and EB007813 (to PT). The funding agencies had no role in the design, acquisition, analysis or reporting the findings of this research. The authors would like to thank Wei Wang for running the FDS code.

PY - 2011/6

Y1 - 2011/6

N2 - The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.

AB - The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.

KW - Basal ganglia

KW - Gray matter

KW - HIV

KW - MRI

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EP - 85

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

IS - 2

ER -

Subcortical brain atrophy persists even in HAART-regulated HIV disease

Abstract

Keywords

ASJC Scopus subject areas

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