Subclinical cardiovascular disease in older adults: insights from the Cardiovascular Health Study.

Paulo H.M. Chaves, Lewis H. Kuller, Daniel H. O'Leary, Teri A. Manolio, Anne B. Newman

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Knowledge about the epidemiology of subclinical cardiovascular disease (SCVD) in older adults may hold the key for improved opportunities for primary prevention of cardiovascular disease (CVD), a top clinical and public health priority. This review reports findings on the prevalence of SCVD and the ability of SCVD measures to predict incident and adverse outcomes from one of the largest (N=5888) and most comprehensive prospective observational studies on SCVD in older adults, the Cardiovascular Health Study. According to a composite index that combined SCVD measures from different vascular beds, the overall prevalence of SCVD was 37%, making it as common as clinically overt CVD in older adults. SCVD measures strongly predicted incident CVD, stroke, mortality, frailty, and physical and cognitive decline, even after adjustment for traditional CVD risk factors. Ongoing research will address the potential use of SCVD for clinical decision making in older adults.

Original languageEnglish (US)
Pages (from-to)137-149
Number of pages13
JournalThe American journal of geriatric cardiology
Issue number3
StatePublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Gerontology
  • Health Policy
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine


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