@article{2474bff7709d4045a298cdea9eec324f,
title = "Subclinical cardiac dysfunction and brain health in midlife: CARDIA (Coronary Artery Risk Development in Young Adults) brain magnetic resonance imaging substudy",
abstract = "Background--We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and Results--This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=-0.002; P < 0.02). The association was strongest in black participants and in men. Conclusions--Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.",
keywords = "Brain, Echocardiography, Epidemiology, Magnetic resonance imaging, White matter, Young adulthood",
author = "Pavla Cermakova and Majon Muller and Armstrong, {Anderson C.} and Dorota Religa and {Nick Bryan}, R. and Lima, {Jo{\~a}o A.C.} and Launer, {Lenore J.}",
note = "Funding Information: The CARDIA (Coronary Artery Risk Development in Young Adults) study is supported by contracts HHSN 268201300025C, HHSN268201300026C, HHSN26820 1300027C, HHSN268201300028C, HHSN268201300029C, and HHSN268200900041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between NIA and NHLBI (AG0005). Cermakova was supported by the Alzheimer Foundation–Czech Republic, the Swedish Research Council (grant 2012-2291), and project “Sustainability for the National Institute of Mental Health” (grant LO1611), with a financial support from the Ministry of Education, Youth and Sports of the Czech Republic. Religa was supported by the Swedish Research Council (grant 2012-2291). This article was reviewed by CARDIA for scientific content. Funding Information: The CARDIA (Coronary Artery Risk Development in Young Adults) study is supported by contracts HHSN 268201300025C, HHSN268201300026C, HHSN26820 1300027C, HHSN268201300028C, HHSN268201300029C, and HHSN268200900041C from the National Heart, Lung, and Blood Institute (NHLBI), the Intramural Research Program of the National Institute on Aging (NIA), and an intra-agency agreement between NIA and NHLBI (AG0005). Cermakova was supported by the Alzheimer Foundation-Czech Republic, the Swedish Research Council (grant 2012-2291), and project 'Sustainability for the National Institute of Mental Health' (grant LO1611), with a financial support from the Ministry of Education, Youth and Sports of the Czech Republic. Religa was supported by the Swedish Research Council (grant 2012-2291). This article was reviewed by CARDIA for scientific content. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2017",
month = dec,
day = "1",
doi = "10.1161/JAHA.117.006750",
language = "English (US)",
volume = "6",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "American Heart Association Inc.",
number = "12",
}