Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Brandilyn A. Peters; Adam Whalen; Xiaonan Xue; Elizabeth F. Topper; Kathleen M. Weber; Phyllis C. Tien; Seble G. Kassaye; Howard Minkoff; Ervin Fox; Margaret A. Fischl; Lauren F. Collins; Michelle Floris-Moore; Howard N. Hodis; Qibin Qi; David B. Hanna; Anjali Sharma; Kathryn Anastos; Robert C. Kaplan

doi:10.1093/infdis/jiad488

Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

Brandilyn A. Peters, Adam Whalen, Xiaonan Xue, Elizabeth F. Topper, Kathleen M. Weber, Phyllis C. Tien, Seble G. Kassaye, Howard Minkoff, Ervin Fox, Margaret A. Fischl, Lauren F. Collins, Michelle Floris-Moore, Howard N. Hodis, Qibin Qi, David B. Hanna, Anjali Sharma, Kathryn Anastos, Robert C. Kaplan

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

Original language	English (US)
Pages (from-to)	780-785
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	229
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiad488
State	Published - Mar 15 2024

Keywords

HIV
atherosclerosis
cardiovascular disease
menopause

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiad488

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Peters, B. A., Whalen, A., Xue, X., Topper, E. F., Weber, K. M., Tien, P. C., Kassaye, S. G., Minkoff, H., Fox, E., Fischl, M. A., Collins, L. F., Floris-Moore, M., Hodis, H. N., Qi, Q., Hanna, D. B., Sharma, A., Anastos, K., & Kaplan, R. C. (2024). Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV. Journal of Infectious Diseases, 229(3), 780-785. https://doi.org/10.1093/infdis/jiad488

Peters, BA, Whalen, A, Xue, X, Topper, EF, Weber, KM, Tien, PC, Kassaye, SG, Minkoff, H, Fox, E, Fischl, MA, Collins, LF, Floris-Moore, M, Hodis, HN, Qi, Q, Hanna, DB, Sharma, A, Anastos, K & Kaplan, RC 2024, 'Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV', Journal of Infectious Diseases, vol. 229, no. 3, pp. 780-785. https://doi.org/10.1093/infdis/jiad488

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title = "Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV",

abstract = "The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women{\textquoteright}s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.",

keywords = "HIV, atherosclerosis, cardiovascular disease, menopause",

author = "Peters, {Brandilyn A.} and Adam Whalen and Xiaonan Xue and Topper, {Elizabeth F.} and Weber, {Kathleen M.} and Tien, {Phyllis C.} and Kassaye, {Seble G.} and Howard Minkoff and Ervin Fox and Fischl, {Margaret A.} and Collins, {Lauren F.} and Michelle Floris-Moore and Hodis, {Howard N.} and Qibin Qi and Hanna, {David B.} and Anjali Sharma and Kathryn Anastos and Kaplan, {Robert C.}",

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doi = "10.1093/infdis/jiad488",

language = "English (US)",

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AU - Peters, Brandilyn A.

AU - Whalen, Adam

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AU - Weber, Kathleen M.

AU - Tien, Phyllis C.

AU - Kassaye, Seble G.

AU - Minkoff, Howard

AU - Fox, Ervin

AU - Fischl, Margaret A.

AU - Collins, Lauren F.

AU - Floris-Moore, Michelle

AU - Hodis, Howard N.

AU - Qi, Qibin

AU - Hanna, David B.

AU - Sharma, Anjali

AU - Anastos, Kathryn

AU - Kaplan, Robert C.

PY - 2024/3/15

Y1 - 2024/3/15

N2 - The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

AB - The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women’s Interagency HIV Study (2004–2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 µm/ year, P = .002); and CIMT increased over time in the pretransition (3.47 µm/year, P = .002) and during the menopausal transition (9.41 µm/year, P < .0001), but not posttransition (2.9 µm/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.

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Subclinical Atherosclerosis Across the Menopausal Transition in Women With and Without HIV

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