Study on the role of inflammatory factors in the cardiovascular toxicity of PM2.5

Yun Hui Zhang; Shen Cao; Jia Wei Ding; Ling Lin; Ni Zhao; Hai Dong Kan

Study on the role of inflammatory factors in the cardiovascular toxicity of PM_2.5

Yun Hui Zhang, Shen Cao, Jia Wei Ding, Ling Lin, Ni Zhao, Hai Dong Kan

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study is to explore the potential role of inflammatory factors in the mechanism of cardiovascular toxicity of PM_2.5. The cardiovascular endothelium cells were treated by PM_2.5 collected from urban area of Shanghai, with doses of 0.01 mg/mL, 0.05 mg/mL and 0.2 mg/mL. The relative concentrations of IL-4 and extaxin mRNA were measured by the method of RT-PCR and compared by t-test. Results showed that the relative concentrations of IL-4 and extaxin mRNA in 0.05 mg/mL and 0.2 mg/mL groups were significantly higher than the control. This result meant that the I-type allergy related inflammatory factors such as IL-4 and extaxin might play an important role on the cardiovascular toxicity of PM_2.5.

Original language	English (US)
Pages (from-to)	16-19
Number of pages	4
Journal	Zhongguo Huanjing Kexue/China Environmental Science
Volume	26
Issue number	1
State	Published - Feb 2006
Externally published	Yes

Keywords

Cardiovascular system
Inflammatory effect
PM

ASJC Scopus subject areas

General Environmental Science

Cite this

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title = "Study on the role of inflammatory factors in the cardiovascular toxicity of PM2.5",

abstract = "The purpose of this study is to explore the potential role of inflammatory factors in the mechanism of cardiovascular toxicity of PM2.5. The cardiovascular endothelium cells were treated by PM2.5 collected from urban area of Shanghai, with doses of 0.01 mg/mL, 0.05 mg/mL and 0.2 mg/mL. The relative concentrations of IL-4 and extaxin mRNA were measured by the method of RT-PCR and compared by t-test. Results showed that the relative concentrations of IL-4 and extaxin mRNA in 0.05 mg/mL and 0.2 mg/mL groups were significantly higher than the control. This result meant that the I-type allergy related inflammatory factors such as IL-4 and extaxin might play an important role on the cardiovascular toxicity of PM2.5.",

keywords = "Cardiovascular system, Inflammatory effect, PM",

author = "Zhang, {Yun Hui} and Shen Cao and Ding, {Jia Wei} and Ling Lin and Ni Zhao and Kan, {Hai Dong}",

year = "2006",

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T1 - Study on the role of inflammatory factors in the cardiovascular toxicity of PM2.5

AU - Zhang, Yun Hui

AU - Cao, Shen

AU - Ding, Jia Wei

AU - Lin, Ling

AU - Zhao, Ni

AU - Kan, Hai Dong

PY - 2006/2

Y1 - 2006/2

N2 - The purpose of this study is to explore the potential role of inflammatory factors in the mechanism of cardiovascular toxicity of PM2.5. The cardiovascular endothelium cells were treated by PM2.5 collected from urban area of Shanghai, with doses of 0.01 mg/mL, 0.05 mg/mL and 0.2 mg/mL. The relative concentrations of IL-4 and extaxin mRNA were measured by the method of RT-PCR and compared by t-test. Results showed that the relative concentrations of IL-4 and extaxin mRNA in 0.05 mg/mL and 0.2 mg/mL groups were significantly higher than the control. This result meant that the I-type allergy related inflammatory factors such as IL-4 and extaxin might play an important role on the cardiovascular toxicity of PM2.5.

AB - The purpose of this study is to explore the potential role of inflammatory factors in the mechanism of cardiovascular toxicity of PM2.5. The cardiovascular endothelium cells were treated by PM2.5 collected from urban area of Shanghai, with doses of 0.01 mg/mL, 0.05 mg/mL and 0.2 mg/mL. The relative concentrations of IL-4 and extaxin mRNA were measured by the method of RT-PCR and compared by t-test. Results showed that the relative concentrations of IL-4 and extaxin mRNA in 0.05 mg/mL and 0.2 mg/mL groups were significantly higher than the control. This result meant that the I-type allergy related inflammatory factors such as IL-4 and extaxin might play an important role on the cardiovascular toxicity of PM2.5.

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KW - Inflammatory effect

KW - PM

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Study on the role of inflammatory factors in the cardiovascular toxicity of PM_2.5

Abstract

Keywords

ASJC Scopus subject areas

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