Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS

Jie Fu; Renxi Zhuo; Changlie Fan

Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS

Jie Fu, Renxi Zhuo, Changlie Fan

Research output: Contribution to journal › Article › peer-review

Abstract

Phosphorus containing copolyanhydrides DECP-CPP and DCPP-CPP were synthesized by melt copolymerization of bis(p-carboxy phenyloxy ethyl), ethyl phosphate (DCPE), bis(p-carboxyphenyloxy ethyl), phenyl phosphate (DCPP) and bis(p-carboxyphenoxy)propane acid (CPP). The copolyanhydrides were characterized by ¹H NMR, IR spectrometry. In Vitro degradation of copolyanhydrides in phosphate buffer solution at 37°C were determined. Drug release profile of Rifampicinum (RFP) were also studied.

Original language	English (US)
Pages (from-to)	X11-470
Journal	Wuhan Daxue Xuebao/Journal of Wuhan University
Volume	43
Issue number	4
State	Published - Dec 1 1997
Externally published	Yes

Keywords

Copolyanhydride
Drug controlled release
Polyphosphate
RFP

ASJC Scopus subject areas

Management of Technology and Innovation

Cite this

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title = "Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS",

abstract = "Phosphorus containing copolyanhydrides DECP-CPP and DCPP-CPP were synthesized by melt copolymerization of bis(p-carboxy phenyloxy ethyl), ethyl phosphate (DCPE), bis(p-carboxyphenyloxy ethyl), phenyl phosphate (DCPP) and bis(p-carboxyphenoxy)propane acid (CPP). The copolyanhydrides were characterized by 1H NMR, IR spectrometry. In Vitro degradation of copolyanhydrides in phosphate buffer solution at 37°C were determined. Drug release profile of Rifampicinum (RFP) were also studied.",

keywords = "Copolyanhydride, Drug controlled release, Polyphosphate, RFP",

author = "Jie Fu and Renxi Zhuo and Changlie Fan",

year = "1997",

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language = "English (US)",

volume = "43",

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T1 - Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS

AU - Fu, Jie

AU - Zhuo, Renxi

AU - Fan, Changlie

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Phosphorus containing copolyanhydrides DECP-CPP and DCPP-CPP were synthesized by melt copolymerization of bis(p-carboxy phenyloxy ethyl), ethyl phosphate (DCPE), bis(p-carboxyphenyloxy ethyl), phenyl phosphate (DCPP) and bis(p-carboxyphenoxy)propane acid (CPP). The copolyanhydrides were characterized by 1H NMR, IR spectrometry. In Vitro degradation of copolyanhydrides in phosphate buffer solution at 37°C were determined. Drug release profile of Rifampicinum (RFP) were also studied.

AB - Phosphorus containing copolyanhydrides DECP-CPP and DCPP-CPP were synthesized by melt copolymerization of bis(p-carboxy phenyloxy ethyl), ethyl phosphate (DCPE), bis(p-carboxyphenyloxy ethyl), phenyl phosphate (DCPP) and bis(p-carboxyphenoxy)propane acid (CPP). The copolyanhydrides were characterized by 1H NMR, IR spectrometry. In Vitro degradation of copolyanhydrides in phosphate buffer solution at 37°C were determined. Drug release profile of Rifampicinum (RFP) were also studied.

KW - Copolyanhydride

KW - Drug controlled release

KW - Polyphosphate

KW - RFP

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VL - 43

SP - X11-470

JO - Wuhan Daxue Xuebao/Journal of Wuhan University

JF - Wuhan Daxue Xuebao/Journal of Wuhan University

IS - 4

ER -

Studies on the melt copolymerization of phosphorus-containing diacid and BIS(p-carboxyphenoxy) propand for DDS

Abstract

Keywords

ASJC Scopus subject areas

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