Studies on the function of the denervated rabbit ovary: human chorionic gonadotropin induced ovulation

S. Weiner; K. H. Wright; E. E. Wallach

doi:10.1016/s0015-0282(16)41058-7

Studies on the function of the denervated rabbit ovary: human chorionic gonadotropin induced ovulation

S. Weiner, K. H. Wright, E. E. Wallach

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10 Scopus citations

Abstract

The described method for selective sympathetic denervation of the in vivo rabbit ovary involved stripping the ovarian artery of its nerve bundles and adventitial tissue. The ovary was then entirely free of fluorescent staining adrenergic nerves. This technique was used to study the effects on ovarian denervation on HCG induced ovulation. After HCG was administered to 22 rabbits which had previously undergone unilateral ovarian denervation, the ovaries were observed for follicular maturation and rupture. Control ovaries demonstrated a mean of 5.6 stimulated follicles/ovary; denervated ovaries had a mean of 5.4. An ruptured. of 3.5 follicles/control ovary ruptured; an average of 3.1 follicles/denervated ovary suptured. Furthermore, the time course of ovulation after HCG did not differ between denervated and intact ovaries. These results indicate that HCG induced ovulation in the rabbit is not interrupted by ovarian denervation.

Original language	English (US)
Pages (from-to)	363-368
Number of pages	6
Journal	Fertility and sterility
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/s0015-0282(16)41058-7
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Studies on the function of the denervated rabbit ovary: human chorionic gonadotropin induced ovulation",

abstract = "The described method for selective sympathetic denervation of the in vivo rabbit ovary involved stripping the ovarian artery of its nerve bundles and adventitial tissue. The ovary was then entirely free of fluorescent staining adrenergic nerves. This technique was used to study the effects on ovarian denervation on HCG induced ovulation. After HCG was administered to 22 rabbits which had previously undergone unilateral ovarian denervation, the ovaries were observed for follicular maturation and rupture. Control ovaries demonstrated a mean of 5.6 stimulated follicles/ovary; denervated ovaries had a mean of 5.4. An ruptured. of 3.5 follicles/control ovary ruptured; an average of 3.1 follicles/denervated ovary suptured. Furthermore, the time course of ovulation after HCG did not differ between denervated and intact ovaries. These results indicate that HCG induced ovulation in the rabbit is not interrupted by ovarian denervation.",

author = "S. Weiner and Wright, {K. H.} and Wallach, {E. E.}",

note = "Funding Information: Received March 27, 1974. *Supported by The Population Council Grant M73.103. tPresented at The 30th Annual Meeting of The American Fertility Society, April 4 to 6, 1974, Hollywood, Florida. *Reprint requests: Stuart Weiner, M.D., Pennsylvannia Hospital, Eighth and Spruce Streets, Philadelphia, Pennsylvania 19107.",

year = "1975",

doi = "10.1016/s0015-0282(16)41058-7",

language = "English (US)",

volume = "26",

pages = "363--368",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Studies on the function of the denervated rabbit ovary

T2 - human chorionic gonadotropin induced ovulation

AU - Weiner, S.

AU - Wright, K. H.

AU - Wallach, E. E.

N1 - Funding Information: Received March 27, 1974. *Supported by The Population Council Grant M73.103. tPresented at The 30th Annual Meeting of The American Fertility Society, April 4 to 6, 1974, Hollywood, Florida. *Reprint requests: Stuart Weiner, M.D., Pennsylvannia Hospital, Eighth and Spruce Streets, Philadelphia, Pennsylvania 19107.

PY - 1975

Y1 - 1975

N2 - The described method for selective sympathetic denervation of the in vivo rabbit ovary involved stripping the ovarian artery of its nerve bundles and adventitial tissue. The ovary was then entirely free of fluorescent staining adrenergic nerves. This technique was used to study the effects on ovarian denervation on HCG induced ovulation. After HCG was administered to 22 rabbits which had previously undergone unilateral ovarian denervation, the ovaries were observed for follicular maturation and rupture. Control ovaries demonstrated a mean of 5.6 stimulated follicles/ovary; denervated ovaries had a mean of 5.4. An ruptured. of 3.5 follicles/control ovary ruptured; an average of 3.1 follicles/denervated ovary suptured. Furthermore, the time course of ovulation after HCG did not differ between denervated and intact ovaries. These results indicate that HCG induced ovulation in the rabbit is not interrupted by ovarian denervation.

AB - The described method for selective sympathetic denervation of the in vivo rabbit ovary involved stripping the ovarian artery of its nerve bundles and adventitial tissue. The ovary was then entirely free of fluorescent staining adrenergic nerves. This technique was used to study the effects on ovarian denervation on HCG induced ovulation. After HCG was administered to 22 rabbits which had previously undergone unilateral ovarian denervation, the ovaries were observed for follicular maturation and rupture. Control ovaries demonstrated a mean of 5.6 stimulated follicles/ovary; denervated ovaries had a mean of 5.4. An ruptured. of 3.5 follicles/control ovary ruptured; an average of 3.1 follicles/denervated ovary suptured. Furthermore, the time course of ovulation after HCG did not differ between denervated and intact ovaries. These results indicate that HCG induced ovulation in the rabbit is not interrupted by ovarian denervation.

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JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Studies on the function of the denervated rabbit ovary: human chorionic gonadotropin induced ovulation

Abstract

ASJC Scopus subject areas

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