Studies on the effect of D-penicillamine on type II collagen-induced polyarthritis

S. S. Kerwar, A. E. Sloboda, J. E. Birnbaum, A. L. Oronsky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The effect of D-penicillamine on a preestablished lesion of type II collagen-induced polyarthritis is reviewed. D-penicillamine treatment (100 and 200 mg/kg/d) for 21 d had no significant effect on rat hind paw inflammation associated with this polyarthritis. At the lower dose, the drug caused an increase in circulating antibody titers to type II collagen. X-ray examination of the hind paws of D-penicillamine-treated animals showed a significant improvement in the joint lesions induced by type II collagen.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalJournal of Rheumatology
Issue numberSuppl. 7
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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