Abstract
The effect of D-penicillamine on a preestablished lesion of type II collagen-induced polyarthritis is reviewed. D-penicillamine treatment (100 and 200 mg/kg/d) for 21 d had no significant effect on rat hind paw inflammation associated with this polyarthritis. At the lower dose, the drug caused an increase in circulating antibody titers to type II collagen. X-ray examination of the hind paws of D-penicillamine-treated animals showed a significant improvement in the joint lesions induced by type II collagen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-89 |
| Number of pages | 6 |
| Journal | Journal of Rheumatology |
| Volume | 8 |
| Issue number | Suppl. 7 |
| State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology