The physiological and pharmacological actions of “saurine” was examined by means of the contraction of intestine of guinea pigs and mice by Magnus method, skin reaction in rabbits, shock symptoms in guinea pigs and antagonism against anti-allergic drugs were tested. The conclusions drawn are as follows: 1. “Saurine” is different from acetylcholine. 2. This poison has merely an additive effect to that of histamine. 3. The skin reaction in rabbits and the shock symptoms in guinea pigs caused by the injection of this substance are similar to those caused by histamine. 4. As for the antagonism between this substance and anti-allergic drugs tested on contraction of intestine, the effect of the drugs was proportional to their antihistaminic activity. 5. These findings mentioned above may suggest that this substance is resembling to histamine in its action.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)