Studies on glucuronide synthesis in rats chronically treated with morphine and phenol

A. E. Takemori; Gerald A. Glowacki

doi:10.1016/0006-2952(62)90182-X

Studies on glucuronide synthesis in rats chronically treated with morphine and phenol

A. E. Takemori, Gerald A. Glowacki

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Glucuronyl transferase activity in rats chronically treated with morphine is decreased whereas that in rats chronically treated with phenol is unchanged when the enzymic activity is compared with that in control rats. The depressed enzymic activity in rats treated with morphine is apparent regardless of whether morphine or phenol is used as the substrate in assaying the activity. The activity of uridine diphosphate (UDP)-glucose dehydrogenase remains unaltered in the experimental animals. The glucuronyl transferase reaction in rats chronically treated with morphine becomes rate-limiting in conjugating foreign substances in the body.

Original language	English (US)
Pages (from-to)	867-870
Number of pages	4
Journal	Biochemical Pharmacology
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/0006-2952(62)90182-X
State	Published - Sep 1962

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(62)90182-X

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title = "Studies on glucuronide synthesis in rats chronically treated with morphine and phenol",

abstract = "Glucuronyl transferase activity in rats chronically treated with morphine is decreased whereas that in rats chronically treated with phenol is unchanged when the enzymic activity is compared with that in control rats. The depressed enzymic activity in rats treated with morphine is apparent regardless of whether morphine or phenol is used as the substrate in assaying the activity. The activity of uridine diphosphate (UDP)-glucose dehydrogenase remains unaltered in the experimental animals. The glucuronyl transferase reaction in rats chronically treated with morphine becomes rate-limiting in conjugating foreign substances in the body.",

author = "Takemori, {A. E.} and Glowacki, {Gerald A.}",

note = "Funding Information: * This investigation was supported by Research Grant M-3897 from the National Institute of Mental Health, United States Public Health Service. t Predoctoral Fellow of the State University of New York, 1960 (supported by the National Institutes of Health). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1962",

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T1 - Studies on glucuronide synthesis in rats chronically treated with morphine and phenol

AU - Takemori, A. E.

AU - Glowacki, Gerald A.

N1 - Funding Information: * This investigation was supported by Research Grant M-3897 from the National Institute of Mental Health, United States Public Health Service. t Predoctoral Fellow of the State University of New York, 1960 (supported by the National Institutes of Health). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1962/9

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N2 - Glucuronyl transferase activity in rats chronically treated with morphine is decreased whereas that in rats chronically treated with phenol is unchanged when the enzymic activity is compared with that in control rats. The depressed enzymic activity in rats treated with morphine is apparent regardless of whether morphine or phenol is used as the substrate in assaying the activity. The activity of uridine diphosphate (UDP)-glucose dehydrogenase remains unaltered in the experimental animals. The glucuronyl transferase reaction in rats chronically treated with morphine becomes rate-limiting in conjugating foreign substances in the body.

AB - Glucuronyl transferase activity in rats chronically treated with morphine is decreased whereas that in rats chronically treated with phenol is unchanged when the enzymic activity is compared with that in control rats. The depressed enzymic activity in rats treated with morphine is apparent regardless of whether morphine or phenol is used as the substrate in assaying the activity. The activity of uridine diphosphate (UDP)-glucose dehydrogenase remains unaltered in the experimental animals. The glucuronyl transferase reaction in rats chronically treated with morphine becomes rate-limiting in conjugating foreign substances in the body.

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Studies on glucuronide synthesis in rats chronically treated with morphine and phenol

Abstract

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