Studies of pancreatic nodule induction and DNA damage by D-azaserine

Joanne Zurlo; Daniel S. Longnecker; David A. Cooney; Elna T. Kuhlmann; Thomas J. Curphey

doi:10.1016/0304-3835(81)90040-9

Studies of pancreatic nodule induction and DNA damage by D-azaserine

Joanne Zurlo, Daniel S. Longnecker, David A. Cooney, Elna T. Kuhlmann, Thomas J. Curphey

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	Cancer Letters
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(81)90040-9
State	Published - Mar 1981

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Studies of pancreatic nodule induction and DNA damage by D-azaserine",

abstract = "The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.",

author = "Joanne Zurlo and Longnecker, {Daniel S.} and Cooney, {David A.} and Kuhlmann, {Elna T.} and Curphey, {Thomas J.}",

note = "Funding Information: *Supported by NIH grant CA 17843. A portion of this work was done in the Laboratory of Toxicology, NCI, Bethesda, MD. Address all correspondence to: Daniel S. Longnecker, M.D. Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03755, U.S.A.",

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doi = "10.1016/0304-3835(81)90040-9",

language = "English (US)",

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journal = "Cancer Letters",

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AU - Zurlo, Joanne

AU - Longnecker, Daniel S.

AU - Cooney, David A.

AU - Kuhlmann, Elna T.

AU - Curphey, Thomas J.

N1 - Funding Information: *Supported by NIH grant CA 17843. A portion of this work was done in the Laboratory of Toxicology, NCI, Bethesda, MD. Address all correspondence to: Daniel S. Longnecker, M.D. Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03755, U.S.A.

PY - 1981/3

Y1 - 1981/3

N2 - The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.

AB - The ability of the D-isomer of azaserine to induce atypical acinar cell nodules (AACN) in pancreas and to cause DNA damage in pancreas and liver was evaluated. Rats were injected with equivalent doses of D- or L-azaserine and numbers of AACN were counted after 4 months. DNA damage in pancreas and liver of rats treated in vivo, and in pancreatic acinar cells treated in vitro with D- or L-azaserine was determined by alkaline elution. Results show that D-azaserine does not significantly induced AACN in pancreas, nor does it cause extensive DNA damage in comparison with L-azaserine, suggesting that the differential effect of the 2 isomers is related to stereospecificity in either transport or metabolism.

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ER -

Studies of pancreatic nodule induction and DNA damage by D-azaserine

Abstract

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