Structure of DNA topoisomerases

James M. Berger

doi:10.1016/S0167-4781(98)00124-9

Structure of DNA topoisomerases

James M. Berger

Research output: Contribution to journal › Review article › peer-review

101 Scopus citations

Abstract

Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase function.

Original language	English (US)
Pages (from-to)	3-18
Number of pages	16
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1400
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-4781(98)00124-9
State	Published - Oct 1 1998
Externally published	Yes

Keywords

Adenosine triphosphate binding
DNA binding
DNA cleavage
Protein structure
Recombinase
Topoisomerase

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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10.1016/S0167-4781(98)00124-9

Cite this

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title = "Structure of DNA topoisomerases",

abstract = "Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase function.",

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AB - Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase function.

KW - Adenosine triphosphate binding

KW - DNA binding

KW - DNA cleavage

KW - Protein structure

KW - Recombinase

KW - Topoisomerase

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AN - SCOPUS:0032189653

SN - 0167-4781

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

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ER -

Structure of DNA topoisomerases

Abstract

Keywords

ASJC Scopus subject areas

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