Structure of DNA topoisomerases

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aided our understanding of the mechanisms of topoisomerase catalysis and drug interactions. This review will cover advances in the structural biology of topoisomerases and discuss their implications for topoisomerase function.

Original languageEnglish (US)
Pages (from-to)3-18
Number of pages16
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Issue number1-3
StatePublished - Oct 1 1998
Externally publishedYes


  • Adenosine triphosphate binding
  • DNA binding
  • DNA cleavage
  • Protein structure
  • Recombinase
  • Topoisomerase

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics


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