TY - JOUR
T1 - Structure and alternative splicing of the gene encoding α(1G), a human brain T calcium channel α1 subunit
AU - Mittman, Scott
AU - Guo, Jing
AU - Agnew, William S.
N1 - Funding Information:
This work was supported by grants from the NIH (K08NS01939 to S.M., P50HL52307 to W.S.A.); and the Foundation for Anesthesia Education and Research, the American Society of Regional Anesthesia and Astra Pharmaceuticals (to S.M.). DNA sequencing was performed by the Institutional Biosynthesis and Sequencing Facility.
PY - 1999/10/29
Y1 - 1999/10/29
N2 - The structure of CACNA1G, the gene encoding α(1G), a human brain T Ca2+ channel α1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66 490 basepairs of chromosome 17q22. Alternative splicing of the RNA occurs at six sites: cassette exons 14, 26, 34 and 35, an internal donor in exon 25 and protein-coding intron 38B. Additionally, the RNA can be polyadenylated at either of two sites. Alternative splicing of CACNA1G RNA may lead to expression of as many as 24 distinct protein products, ranging from 2171 to 2377 amino-acids residues. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - The structure of CACNA1G, the gene encoding α(1G), a human brain T Ca2+ channel α1 subunit, was determined by comparison of polymerase chain reaction-amplified brain cDNA and genomic sequences. The gene consists of at least 38 exons, two of them newly-identified, spanning at least 66 490 basepairs of chromosome 17q22. Alternative splicing of the RNA occurs at six sites: cassette exons 14, 26, 34 and 35, an internal donor in exon 25 and protein-coding intron 38B. Additionally, the RNA can be polyadenylated at either of two sites. Alternative splicing of CACNA1G RNA may lead to expression of as many as 24 distinct protein products, ranging from 2171 to 2377 amino-acids residues. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Alternative splicing
KW - CACNA1G
KW - T-type calcium channel
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U2 - 10.1016/S0304-3940(99)00716-8
DO - 10.1016/S0304-3940(99)00716-8
M3 - Article
C2 - 10548410
AN - SCOPUS:0032826784
SN - 0304-3940
VL - 274
SP - 143
EP - 146
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -