The swelling pressure of the corneal stroma is discussed in terms of a stromal model of collagen fibrils interconnected via protein-mucopolysaccharide molecular complexes. The analysis leads to an expression for the swelling pressure in terms of molecular parameters of the complexes regarded as polymeric chains. Assigning reasonable values to these parameters we find that the model is consistent with the swelling pressure experiments. These parameters indicate the electrostatic (Donnan) pressure component accounts for most of the swelling pressure at normal thickness in 0.174 M NaCl, while the pressure components deriving from a free energy of mixing account for most of the swelling pressure at normal thickness in 1.74 M NaCl.
ASJC Scopus subject areas
- General Neuroscience
- General Mathematics
- General Biochemistry, Genetics and Molecular Biology
- General Environmental Science
- General Agricultural and Biological Sciences
- Computational Theory and Mathematics