Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Alan P. Kozikowski; Lianyun Zhao; Ao Zhang; Cheng Z. Wang; Judith Flippen-Anderson; Kenneth M. Johnson

doi:10.1002/cmdc.200500016

Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Alan P. Kozikowski, Lianyun Zhao, Ao Zhang, Cheng Z. Wang, Judith Flippen-Anderson, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.

Original language	English (US)
Pages (from-to)	58-65
Number of pages	8
Journal	ChemMedChem
Volume	1
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.200500016
State	Published - Jan 2006
Externally published	Yes

Keywords

Cocaine
Cyclopropane
Monoamine inhibitors
Neurochemistry
Neurotransmitters

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1002/cmdc.200500016

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keywords = "Cocaine, Cyclopropane, Monoamine inhibitors, Neurochemistry, Neurotransmitters",

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AU - Zhao, Lianyun

AU - Zhang, Ao

AU - Wang, Cheng Z.

AU - Flippen-Anderson, Judith

AU - Johnson, Kenneth M.

PY - 2006/1

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AB - Blocking transporters: A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.

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KW - Cyclopropane

KW - Monoamine inhibitors

KW - Neurochemistry

KW - Neurotransmitters

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Structural remodeling of cocaine: Design and synthesis of trisubstituted cyclopropanes as selective serotonin reuptake inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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