The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein-nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.
|Original language||English (US)|
|Number of pages||30|
|Journal||Annual review of biochemistry|
|State||Published - Jun 20 2021|
- Clamp loader
- DNA replication
ASJC Scopus subject areas