Structural Mechanisms for Replicating DNA in Eukaryotes

Ilan Attali, Michael R. Botchan, James M. Berger

Research output: Contribution to journalReview articlepeer-review


The faithful and timely copying of DNA by molecular machines known as replisomes depends on a disparate suite of enzymes and scaffolding factors working together in a highly orchestrated manner. Large, dynamic protein-nucleic acid assemblies that selectively morph between distinct conformations and compositional states underpin this critical cellular process. In this article, we discuss recent progress outlining the physical basis of replisome construction and progression in eukaryotes.

Original languageEnglish (US)
Pages (from-to)77-106
Number of pages30
JournalAnnual review of biochemistry
StatePublished - Jun 20 2021


  • ATPase
  • Clamp loader
  • DNA replication
  • Helicase
  • MCM
  • ORC
  • PCNA
  • Polymerase
  • Primase

ASJC Scopus subject areas

  • Biochemistry


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