Structural insights into the rodent CNS via diffusion tensor imaging

Jiangyang Zhang, Manisha Aggarwal, Susumu Mori

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Diffusion tensor imaging (DTI) is a useful tool for studying anatomy and pathology in the rodent central nervous system (CNS).The unique tissue contrasts provided by DTI are well suited for monitoring disease progression, studying brain development, and characterizing anatomical phenotypes. Recent technical developments have vastly improved the speed and resolution of rodent DTI. Ongoing research efforts exploring the microstructural basis of DTI signals have provided useful insights into its capabilities to delineate brain structures and detect neuropathology. Significant progress has also been made in combining DTI results with data acquired using other imaging modalities to enhance our understanding of the rodent CNS.

Original languageEnglish (US)
Pages (from-to)412-421
Number of pages10
JournalTrends in neurosciences
Issue number7
StatePublished - Jul 2012


  • Brain
  • Diffusion tensor imaging
  • Neuroanatomy
  • Rodent
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)


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