Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue; Michelle Boahbedason; Ronghui Wu; Patrick M. Woster; Robert A. Casero; Donna Rattendi; Schennella Lane; Cyrus J. Bacchi

doi:10.1016/S0960-894X(96)00510-0

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Frank H. Bellevue, Michelle Boahbedason, Ronghui Wu, Patrick M. Woster, Robert A. Casero, Donna Rattendi, Schennella Lane, Cyrus J. Bacchi

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.

Original language	English (US)
Pages (from-to)	2765-2770
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	22
DOIs	https://doi.org/10.1016/S0960-894X(96)00510-0
State	Published - Nov 19 1996

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(96)00510-0

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title = "Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity",

abstract = "A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.",

author = "Bellevue, {Frank H.} and Michelle Boahbedason and Ronghui Wu and Woster, {Patrick M.} and Casero, {Robert A.} and Donna Rattendi and Schennella Lane and Bacchi, {Cyrus J.}",

note = "Funding Information: Acknowledgements. This research was supported by National Institutes of Health grants CA63552 (PMW), CA51085 (RAC) and CA58184 (RAC). In addition, this investigation received financial support from the UNDP/WORLD BANK/WHO Special Programme for Research and Training in Tropical Diseases (PMW, CJB). The excellent technical assistance of Ms. Alexis Mesa is gratefully acknowledged.",

year = "1996",

month = nov,

day = "19",

doi = "10.1016/S0960-894X(96)00510-0",

language = "English (US)",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

AU - Bellevue, Frank H.

AU - Boahbedason, Michelle

AU - Wu, Ronghui

AU - Woster, Patrick M.

AU - Casero, Robert A.

AU - Rattendi, Donna

AU - Lane, Schennella

AU - Bacchi, Cyrus J.

N1 - Funding Information: Acknowledgements. This research was supported by National Institutes of Health grants CA63552 (PMW), CA51085 (RAC) and CA58184 (RAC). In addition, this investigation received financial support from the UNDP/WORLD BANK/WHO Special Programme for Research and Training in Tropical Diseases (PMW, CJB). The excellent technical assistance of Ms. Alexis Mesa is gratefully acknowledged.

PY - 1996/11/19

Y1 - 1996/11/19

N2 - A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.

AB - A series of symmetrically or unsymmetrically alkyl-substituted polyamine analogues were synthesized containing either a 3-3-3 or 3-7-3 polyamine backbone. These analogues were evaluated in vitro as antitumor agents in the NCI H157 and NCI H82 lung carcinoma cell lines, and as antitrypanosomal agents against four strains of Trypanosoma brucei brucei or Trypanosoma brucei rhodesiense. The resulting biological data suggest that it is possible to specifically target tumor cells or parasitic organisms with alkylpolyamine analogues based on structure.

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ER -

Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity

Abstract

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