TY - JOUR
T1 - Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells
AU - Klonisch, Thomas
AU - Glogowska, Aleksandra
AU - Thanasupawat, Thatchawan
AU - Burg, Maxwell
AU - Krcek, Jerry
AU - Pitz, Marshall
AU - Jaggupilli, Appalaraju
AU - Chelikani, Prashen
AU - Wong, G. William
AU - Hombach-Klonisch, Sabine
N1 - Publisher Copyright:
© 2016 The British Pharmacological Society
PY - 2017
Y1 - 2017
N2 - We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors. Linked Articles: This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.
AB - We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors. Linked Articles: This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.
UR - http://www.scopus.com/inward/record.url?scp=84981492527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981492527&partnerID=8YFLogxK
U2 - 10.1111/bph.13559
DO - 10.1111/bph.13559
M3 - Article
C2 - 27443788
AN - SCOPUS:84981492527
SN - 0007-1188
VL - 174
SP - 1025
EP - 1033
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 10
ER -